RRIDs were included in this in Proceedings of the National Academy of Sciences paper. We value the author's support of reproducibility. #STMpublishing #OpenScience #RRID
Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis
Read the full paper: Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis
doi.org
October 30, 2026 at 7:01 AM
RRIDs were included in this in Proceedings of the National Academy of Sciences paper. We value the author's support of reproducibility. #STMpublishing #OpenScience #RRID
Discoveries reveal VPS13A and XK scramblase form a complex facilitating lipid transfer between organelles. Cryo-EM uncovers the mechanics of this crucial interaction. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
November 2, 2026 at 7:00 PM
Cryo-EM reveals the VPS13A BLTP partnering with XK scramblase, showcasing a novel lipid transfer mechanism across organelle contact sites. Key insights on lipid delivery dynamics! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
November 1, 2026 at 7:00 PM
VPS13A, a bridge-like lipid-transfer protein, forms a complex with scramblase XK at organelle contact sites, using hydrophobic channels for lipid transfer. Cryo-EM reveals the intricate cooperation vital for… PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
October 27, 2026 at 3:00 AM
VPS13A, a bridge-like lipid-transfer protein, forms a complex with scramblase XK at organelle contact sites, using hydrophobic channels for lipid transfer. Cryo-EM reveals the intricate cooperation vital for… PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
Cryo-EM reveals the VPS13A-BLTP complex working with scramblase XK, facilitating lipid transfer between organelles—key for eukaryotic function! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
October 23, 2026 at 8:00 PM
Innovative cryo-EM reveals the VPS13A-BLTP complex with scramblase XK, uncovering how 7 nm hydrophobic channels mediate lipid transfer at organelle contact sites. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
October 22, 2026 at 5:00 AM
Detergent-based preparation influences TMEM16F assembly and scramblase activity pubmed.ncbi.nlm.nih.gov/42887390/ #cryoem
October 17, 2026 at 11:46 AM
Detergent-based preparation influences TMEM16F assembly and scramblase activity pubmed.ncbi.nlm.nih.gov/42887390/ #cryoem
How these lipid pipelines deliver lipid to both sides of their target membrane - using a scramblase to supply and grow both sheets of the lipid bilayer
New insights into lipid transfer reveal that VPS13A, a bridge-like lipid-transfer protein, forms a complex with the scramblase XK, facilitating organelle communication. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
October 13, 2026 at 10:18 PM
How these lipid pipelines deliver lipid to both sides of their target membrane - using a scramblase to supply and grow both sheets of the lipid bilayer
New insights into lipid transfer reveal that VPS13A, a bridge-like lipid-transfer protein, forms a complex with the scramblase XK, facilitating organelle communication. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
October 11, 2026 at 6:00 PM
New insights reveal how VPS13A, a bridge-like lipid-transfer protein, collaborates with the scramblase XK via cryo-EM to mediate lipid transfer at organelle contact sites. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
October 9, 2026 at 11:00 PM
Exciting insights on VPS13A, a bridge-like lipid transfer protein, reveal its complex with scramblase XK, illuminating lipid transfer mechanisms at organelle contact sites! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
October 4, 2026 at 9:00 PM
📰 The molecular mechanism that regulates TMEM63B lipid scrambling
TMEM63B, a mechanosensitive lipid scramblase, has an autoinhibitory domain in its C-terminal tail that helps keep it inactive under...
Source: Phys.org | Read story
💬 What's your take on this tech shift?
#TechBluesky #Lipid #Keep
TMEM63B, a mechanosensitive lipid scramblase, has an autoinhibitory domain in its C-terminal tail that helps keep it inactive under...
Source: Phys.org | Read story
💬 What's your take on this tech shift?
#TechBluesky #Lipid #Keep
The molecular mechanism that regulates TMEM63B lipid scrambling
TMEM63B, a mechanosensitive lipid scramblase, has an autoinhibitory domain in its C-terminal tail that helps keep it inactive under...
phys.org
September 29, 2026 at 2:24 PM
📰 The molecular mechanism that regulates TMEM63B lipid scrambling
TMEM63B, a mechanosensitive lipid scramblase, has an autoinhibitory domain in its C-terminal tail that helps keep it inactive under...
Source: Phys.org | Read story
💬 What's your take on this tech shift?
#TechBluesky #Lipid #Keep
TMEM63B, a mechanosensitive lipid scramblase, has an autoinhibitory domain in its C-terminal tail that helps keep it inactive under...
Source: Phys.org | Read story
💬 What's your take on this tech shift?
#TechBluesky #Lipid #Keep
Cryo-EM reveals VPS13A's complex with scramblase XK, highlighting their roles in vesicle-independent lipid transfer across organelle contact sites. Insightful collaboration! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
September 22, 2026 at 10:00 PM
Novel insights reveal that VPS13A, a bridge-like lipid-transfer protein, works with scramblase XK to mediate lipid transport at organelle contact sites, utilizing hydrophobic channels. Cryo-EM images deepen… PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
September 20, 2026 at 10:00 AM
Novel insights reveal that VPS13A, a bridge-like lipid-transfer protein, works with scramblase XK to mediate lipid transport at organelle contact sites, utilizing hydrophobic channels. Cryo-EM images deepen… PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
Exciting findings reveal that VPS13A, a bridge-like lipid-transfer protein, interacts with scramblase XK, facilitating lipid transfer between organelles via hydrophobic channels! #CellBiology PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
September 17, 2026 at 7:00 AM
Exciting findings reveal that VPS13A, a bridge-like lipid-transfer protein, interacts with scramblase XK, facilitating lipid transfer between organelles via hydrophobic channels! #CellBiology PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky 🧪
New insights reveal the complex of BLTP VPS13A and scramblase XK, visualized by cryo-EM, enhances lipid transfer between organelles, crucial for cellular function. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
September 13, 2026 at 7:00 AM
New insights reveal how VPS13A, a bridge-like lipid-transfer protein, cooperates with scramblase XK to mediate lipid transfer via hydrophobic channels—essential for organelle communication! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
September 5, 2026 at 9:00 PM
New insights reveal how VPS13A, a bridge-like lipid-transfer protein, cooperates with scramblase XK to mediate lipid transfer via hydrophobic channels—essential for organelle communication! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky 🧪
Any1 is a #phospholipid scramblase involved in #endosome biogenesis. From Jieqiong Gao, @labvanni.bsky.social, Christian Ungermann and colleagues: rupress.org/jcb/article/...
📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti...
#EMBOLipidCode
📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti...
#EMBOLipidCode
September 4, 2026 at 1:15 PM
Any1 is a #phospholipid scramblase involved in #endosome biogenesis. From Jieqiong Gao, @labvanni.bsky.social, Christian Ungermann and colleagues: rupress.org/jcb/article/...
📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti...
#EMBOLipidCode
📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti...
#EMBOLipidCode
New insights into lipid transfer revealed! Cryo-EM shows VPS13A bridges organelles, working with XK scramblase to facilitate crucial lipid movement. Exciting steps in eukaryotic cell biology! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
September 3, 2026 at 8:00 AM
New insights into lipid transfer revealed! Cryo-EM shows VPS13A bridges organelles, working with XK scramblase to facilitate crucial lipid movement. Exciting steps in eukaryotic cell biology! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky 🧪
Cryo-EM reveals VPS13A, a bridge-like lipid transfer protein, interacts with scramblase XK, uncoding how lipid delivery occurs between organelles. Key insights on membrane dynamics! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
August 30, 2026 at 3:00 AM
Cryo-EM reveals VPS13A, a bridge-like lipid transfer protein, interacts with scramblase XK, uncoding how lipid delivery occurs between organelles. Key insights on membrane dynamics! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA 🧪
ARMC1 regulates mitochondrial fatty acid oxidation through theinsertase/scramblase MTCH2 https://www.biorxiv.org/content/10.64898/2026.08.26.747330v1
August 27, 2026 at 1:30 PM
ARMC1 regulates mitochondrial fatty acid oxidation through theinsertase/scramblase MTCH2 https://www.biorxiv.org/content/10.64898/2026.08.26.747330v1
ARMC1 regulates mitochondrial fatty acid oxidation through theinsertase/scramblase MTCH2 https://www.biorxiv.org/content/10.64898/2026.08.26.747330v1
August 27, 2026 at 1:30 PM
ARMC1 regulates mitochondrial fatty acid oxidation through theinsertase/scramblase MTCH2 https://www.biorxiv.org/content/10.64898/2026.08.26.747330v1
New insights reveal that VPS13A and scramblase XK work together in lipid transfer between organelles using cryo-EM, highlighting mechanisms vital for cellular functions. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
August 26, 2026 at 1:00 AM
New insights into VPS13A reveal how this bridge-like lipid-transfer protein collaborates with scramblase XK to facilitate organelle lipid exchange via hydrophobic channels. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6
No description available
www.cell.com
August 23, 2026 at 8:00 PM
A TMEM63B variant with enhanced mechanosensitive channel activity and acquired #lipid scramblase function. New study from Augustus J. Lowry, Huanghe Yang @huanghe-lab.bsky.social & colleagues @duke-university.bsky.social:
rupress.org/jgp/article/...
#IonChannels #Pathophysiology #MembraneTransport
rupress.org/jgp/article/...
#IonChannels #Pathophysiology #MembraneTransport
August 17, 2026 at 1:45 PM
A TMEM63B variant with enhanced mechanosensitive channel activity and acquired #lipid scramblase function. New study from Augustus J. Lowry, Huanghe Yang @huanghe-lab.bsky.social & colleagues @duke-university.bsky.social:
rupress.org/jgp/article/...
#IonChannels #Pathophysiology #MembraneTransport
rupress.org/jgp/article/...
#IonChannels #Pathophysiology #MembraneTransport