#TGFbeta
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northwell-journals.bsky.social
Molecular Medicine - Journal
Article in Press: TGF-β1 signaling in Crohn’s disease | #MolecularMedicine #TGFbeta #CrohnsDisease link.springer.com/article/10.1...
TGF-β1 signaling in Crohn’s disease - Molecular Medicine
Crohn's disease (CD), a chronic inflammatory disorder of the gastrointestinal tract, arises from the intricate interplay among genetic predisposition, environmental triggers, and gut microbial communi...
link.springer.com
September 23, 2026 at 3:37 PM
haoyin.bsky.social
Congratulations !🥳

It is super-intriguing to see a regenerating zone with quenched TGFbeta-signaling AND exacerbated fibrogenesis😎
September 11, 2026 at 5:35 PM
valeriewittamer.bsky.social
5/5 🥳Congratulations to PhD students Magali Miserocchi and Pauline De Meyer, who drove the study, and big thanks to our collaborators from the @stainierlab.bsky.social 🤩

#Microglia #Neuroimmunology #Zebrafish #DevelopmentalBiology #TGFbeta
August 25, 2026 at 6:52 PM
northwell-journals.bsky.social
Molecular Medicine-Article In Press: Human podocytes uniquely express CD47 to limit ITGAV-dependent TGF-β signaling for protection #Kidney #Podocytes #CD47 #TGFbeta link.springer.com/article/10.1...
Figure 9. CD47 restrains ITGAV-dependent TGF-β activation to protect podocytes. CD47 interacts with ITGAV on the podocyte membrane and limits local activation of latent TGF-β, thereby maintaining low Smad2/3 signaling and podocyte stability. Under stress, CD47 reduction removes this restraint, allowing ITGAV dependent TGF-β activation and downstream Smad2/3 nuclear signaling, which promotes cytoskeletal disruption, CDC42 loss, dedifferentiation, and podocyte injury.
August 24, 2026 at 3:33 PM
bigearthdata.ai
TIF1γ regulates stability of regulatory T cells during inflammation
->Nature | More on "Immune regulation and inflammatory response" at BigEarthData.ai
TIF1γ regulates stability of regulatory T cells during inflammation
Yu, C. et al. The roles of TIF1γ in cancer. Front. Oncol. 9, 979 (2019). Dupont, S. et al. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell 136, 123–135 (2009). Quéré, R. et al. Tif1γ regulates the TGF-β 1 receptor and promotes physiological aging of hematopoietic stem cells. Proc. Natl Acad. Sci. USA 111, 10592–10597 (2014). Xue, J. et al. Tumour suppressor TRIM33 targets nuclear β-catenin degradation. Nat. Commun. 6, 6156 (2015). He, W. et al. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell 125, 929–941 (2006). Chen, W. TGF-β regulation of T cells. Annu. Rev. Immunol. 41, 483–512 (2023). Tai, X. et al. How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion. Nat. Immunol. 24, 637–651 (2023). Chen, W. et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198, 1875–1886 (2003). Rao, P. E., Petrone, A. L. & Ponath, P. D. Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-beta. J. Immunol. 174, 1446–1455 (2005). Moreau, J. M...
www.nature.com
August 11, 2026 at 8:16 PM
sigtrans-sttt.bsky.social
Dual inhibition of NADPH oxidase 1/4 impairs TGF-β-driven protumorigenic effects in cholangiocarcinoma-associated fibroblasts, highlighting a promising therapeutic strategy.
www.nature.com/articles/s41...
#NADPHOxidase #TGFbeta #Cholangiocarcinoma #CancerAssociatedFibroblasts #TumorMicroenvironment
June 30, 2026 at 8:39 AM
matthiassoller.bsky.social
Fascinating story about the organiser discovered over 100 years ago by Mangold & Spemann. A key role for TGFbeta signalling.
June 18, 2026 at 6:42 AM
reitergroup.bsky.social
Ooh! Ctenophores have organizers that probably use TGFbeta/Activin! Tickles both the develolmemtal biologist and the evolutionary biologist. Hilde Mangold would have loved this: www.nature.com/articles/s41...
A blastoporal organizer in a ctenophore - Nature
Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transit...
www.nature.com
June 17, 2026 at 9:35 PM
fly-yang.bsky.social
Very nice work! Inhibition of Hippo signaling, activation of Wnt signaling and TGFbeta signaling give rise to MTSC. J Zhang: Mouse trophectoderm stem cells generated with morula signalling inducers capture an
early trophectoderm state
Mouse trophectoderm stem cells generated with morula signalling inducers capture an early trophectoderm state - Nature Cell Biology
Gao, Li and colleagues derive trophectoderm stem cells from 32-cell mouse embryos. These cells represent an early trophectoderm state and are capable of developing into placenta cells, forming placent...
www.nature.com
June 11, 2026 at 1:05 PM
pflugers-archiv.bsky.social
The May 2026 issue is out with exciting reviews on exercise-modulated microRNAs in skeletal muscle remodelling and TGFbeta signaling in chronic kidney injury

link.springer.com/journal/424/...
Pflügers Archiv - European Journal of Physiology
Pflügers ArchivEuropean Journal of Physiology is the official journal of the German Physiological Society, publishing high-quality original research in ...
link.springer.com
June 1, 2026 at 6:31 AM
cell-regeneration.bsky.social
📨Cell Regen Meeting Report | Recent advances in TGF-β signaling: from regulation to clinical translation! Insights into Smad & non-Smad pathways, embryonic development, stem cells, and disease treatment. #TGFbeta #StemCells
🔗 Full paper at: doi.org/10.1186/s136...
DOI: https://doi.org/10.1186/s13619-026-00286-w
April 28, 2026 at 8:21 AM
irbbarcelona.org
🧲 "Atraer y retener el talento con un centenar de becas a jóvenes investigadores"

📰 La Razón

➡️ https://shorturl.at/VgJut

📸 Jana Bagan (#IRBBarcelona, @maciaslab.bsky.social) y Catalina Vela (@ki.se), investigadoras y beneficiarias de las becas de la Fundación La Caixa.

#TGFBeta #SMAD
March 18, 2026 at 11:06 AM
arula-ratnakar.bsky.social
The motor neurons are specified of an overlap of Pax6 and NKX6.1, where TGFβ inhibits NKX6.1, TGFβ drives Pax6, and Shh inhibits Pax6 and Shh drives NKX6.1. That in-between region where both Pax6 and NKX6.1 are expressed is where you get motor neurons. (11/n)
Motor neurons are where you have both Nkx6.1 and Pax6. Shh inhibits Pax6 and drives expression of Nkx6.1 while TGFbeta drives expression of Pax6 and inhibits Nkx6.1
February 14, 2026 at 11:48 PM
arula-ratnakar.bsky.social
TGFβ & Shh gradients arise along the dorsal ventral axis of the spinal cord, which subdivides it into several distinct layers of neuron types. For example, motor neurons are specified with a moderate Shh threshold, and sit on top of another layer of neurons immediately adjacent to floor plate(10/n)
motor neuron region region is in the middle (closer to notochord) of the TGFbeta Shh gradient. Above and below it are other interneuron types.
February 14, 2026 at 11:46 PM
arula-ratnakar.bsky.social
I’m going to talk about the spinal cord before moving to the brain. In the process of forming the neural tube, you can see that once the neural tube has closed, we have the notochord on one side and a layer of epidermis on the other. (8/n)
Epidermis is sending TGFbeta down, Notochord sending Shh up, defining regions of the part of the neural tube that will become the spinal cord called the floor plate (Shh high) and Roof plate (TGFbeta high)
February 14, 2026 at 11:42 PM
pharmaphorum.bsky.social
#JiangsuHengruiPharma has chalked up a first-in-class approval for retlirafusp alfa, a #bifunctionaldrug that targets #PDL1 and #TGFbeta, as a treatment for advanced #gastriccancer.

pharmaphorum.com/news/hengrui...
January 8, 2026 at 12:52 PM
irbbarcelona.org
🗣️ Dr. @hoheyn.bsky.social (@cnag-ffm.bsky.social eu.bsky.social): “Applying state-of-the-art technology, we observed how #TGFbeta blocks #immunotherapy efficacy and identified new therapeutic targets to improve #ColorectalCancer treatments.”
November 7, 2025 at 10:01 AM
irbbarcelona.org
On the one hand, #TGFbeta prevents a sufficient number of T lymphocytes (the cells responsible for eliminating #cancer cells) from reaching the tumour from the blood. On the other hand, it blocks the expansion of the few T cells that manage to infiltrate the tumour.
November 7, 2025 at 10:01 AM
irbbarcelona.org
Published in @natgenet.nature.com, the study reveals how, via a hormone called #TGFbeta, colorectal tumours build a dual barrier that prevents cells from the immune system from acting against the #cancer.
November 7, 2025 at 10:01 AM
springerlab.bsky.social
🔬 Welcome to the Springer Lab

Follow along to see how structure, mechanics, and biology come together to shape life at the molecular level.

#Integrins #TGFbeta #Mechanobiology #StructuralBiology #Biophysics #Organoids #RegenerativeMedicine #SpringerLab
October 30, 2025 at 7:17 PM
mtobiasch.bsky.social
… of cellular recovery (and the viennese TGFbeta data could support this) - weren‘t this also a misclassification, leading to wrong treatments and wrong research questions asked, hence no progress? A less stigmatising misclassification, granted, but still?
October 26, 2025 at 8:21 PM
amandatatler.bsky.social
The only lung person presenting to some of the greats of the TGFb signalling world 🌍

TGFbeta driven remodelling and fibrosis across lung diseases, from airways to alveoli, and from babies to diseases of advanced age 😎
October 24, 2025 at 11:01 AM
amandatatler.bsky.social
Meeting a TGFbeta legend! Peter ten Dijke, the man who first identified and isolated TGFbeta3
October 24, 2025 at 2:57 AM
giuliaderossi.bsky.social
Once secreted, LRG1 acts on pericytes through TGFbeta signalling, driving them toward a more contractile and fibrotic phenotype.
We observed increased myosin light chain activation and thickened basement membrane in diabetic wild-type mice, but not in those lacking Lrg1.
October 23, 2025 at 8:14 AM