Verrückter Fakt des Tages: #vfdt
Tiefseefische riechen fischiger als oberflächennahe Fische. Spezies die tief unten leben, enthalten mehr TMAO, ein Molekül, das Proteinfehlfaltungen durch extremen Druck verhindert. TMAO wandelt sich dann in TMA um, das für den typischen Fischgeruch sorgt.
Tiefseefische riechen fischiger als oberflächennahe Fische. Spezies die tief unten leben, enthalten mehr TMAO, ein Molekül, das Proteinfehlfaltungen durch extremen Druck verhindert. TMAO wandelt sich dann in TMA um, das für den typischen Fischgeruch sorgt.
May 3, 2026 at 2:34 PM
Verrückter Fakt des Tages: #vfdt
Tiefseefische riechen fischiger als oberflächennahe Fische. Spezies die tief unten leben, enthalten mehr TMAO, ein Molekül, das Proteinfehlfaltungen durch extremen Druck verhindert. TMAO wandelt sich dann in TMA um, das für den typischen Fischgeruch sorgt.
Tiefseefische riechen fischiger als oberflächennahe Fische. Spezies die tief unten leben, enthalten mehr TMAO, ein Molekül, das Proteinfehlfaltungen durch extremen Druck verhindert. TMAO wandelt sich dann in TMA um, das für den typischen Fischgeruch sorgt.
Adipocyte FMO3 and TMAO increase in ageing, causing WAT dysfunction and metabolic issues. Blocking FMO3 reduces TMAO and improves health markers. PMID:41053195, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-63905-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Adipocyte FMO3-derived TMAO induces WAT dysfunction and metabolic disorders by promoting inflammasome activation in ageing | Nature Communications
Trimethylamine N-oxide (TMAO) contributes to cardio-metabolic diseases, with hepatic flavin-containing monooxygenase 3 (FMO3) recognized as its primary source. Here we demonstrate that elevated adipocyte FMO3 and its derived TMAO trigger white adipose tissue (WAT) dysfunction and its related metabolic disorders in ageing. In adipocytes, ageing or p53 activation upregulates FMO3 and TMAO levels. Adipocyte-specific ablation of FMO3 attenuates TMAO accumulation in WAT and circulation, leading to enhanced glucose metabolism and energy and lipid homeostasis in ageing and obese mice. These improvements are associated with reduced senescence, fibrosis and inflammation in WAT. Proteomics analysis identified TMAO-interacting proteins involved in inflammasome activation in adipocytes and macrophages. Mechanistically, TMAO binds to the central inflammasome adaptor protein ASC, promoting caspase-1 activation and interleukin-1β production. Our findings uncover a pivotal role for adipocyte FMO3 in m
doi.org
October 19, 2025 at 3:10 AM
【腸内細菌の代謝産物TMAOと不整脈の関連性】
EBIS世界の最新健康・栄養ニュース
2026年8月7日 06:19
赤肉などの動物性食品に含まれる栄養素を腸内細菌が代謝することで生じるトリメチルアミン-N-オキシド（TMAO）の血中濃度が高い人は、心房細動のリスクが高い可能性があるようだ、という研究報告。
研究チームは、心臓の処置を受けた5,000人以上から採取された血液試料を分析した。さらに、TMAOが心臓にどのような影響を与えるのかを詳しく検討するため、細胞を用いた実験も実施した。
#栄養 #健康
詳しくはこちら↓
note.com/linkdediet/n...
EBIS世界の最新健康・栄養ニュース
2026年8月7日 06:19
赤肉などの動物性食品に含まれる栄養素を腸内細菌が代謝することで生じるトリメチルアミン-N-オキシド（TMAO）の血中濃度が高い人は、心房細動のリスクが高い可能性があるようだ、という研究報告。
研究チームは、心臓の処置を受けた5,000人以上から採取された血液試料を分析した。さらに、TMAOが心臓にどのような影響を与えるのかを詳しく検討するため、細胞を用いた実験も実施した。
#栄養 #健康
詳しくはこちら↓
note.com/linkdediet/n...
腸内細菌の代謝産物TMAOと不整脈の関連性｜EBIS世界の最新健康・栄養ニュース
赤肉などの動物性食品に含まれる栄養素を腸内細菌が代謝することで生じるトリメチルアミン-N-オキシド（TMAO）の血中濃度が高い人は、心房細動のリスクが高い可能性があるようだ、という研究報告。 米国クリーブランド・クリニックを中心とする研究チームは、心臓の処置を受けた5,000人以上から採取された血液試料を分析し、TMAOの血中濃度と心房細動との関係を調べた。さらに、TMAOが心臓にどのような影響...
note.com
August 6, 2026 at 9:30 PM
【腸内細菌の代謝産物TMAOと不整脈の関連性】
EBIS世界の最新健康・栄養ニュース
2026年8月7日 06:19
赤肉などの動物性食品に含まれる栄養素を腸内細菌が代謝することで生じるトリメチルアミン-N-オキシド（TMAO）の血中濃度が高い人は、心房細動のリスクが高い可能性があるようだ、という研究報告。
研究チームは、心臓の処置を受けた5,000人以上から採取された血液試料を分析した。さらに、TMAOが心臓にどのような影響を与えるのかを詳しく検討するため、細胞を用いた実験も実施した。
#栄養 #健康
詳しくはこちら↓
note.com/linkdediet/n...
EBIS世界の最新健康・栄養ニュース
2026年8月7日 06:19
赤肉などの動物性食品に含まれる栄養素を腸内細菌が代謝することで生じるトリメチルアミン-N-オキシド（TMAO）の血中濃度が高い人は、心房細動のリスクが高い可能性があるようだ、という研究報告。
研究チームは、心臓の処置を受けた5,000人以上から採取された血液試料を分析した。さらに、TMAOが心臓にどのような影響を与えるのかを詳しく検討するため、細胞を用いた実験も実施した。
#栄養 #健康
詳しくはこちら↓
note.com/linkdediet/n...
RESEARCH | J Chilloux, @marcedumas.bsky.social et al. (Imperial College London)
The microbial metabolite TMA (precursor of TMAO) has beneficial metabolic and anti-inflammatory effects🧪
The microbial metabolite TMA (precursor of TMAO) has beneficial metabolic and anti-inflammatory effects🧪
Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control - Nature Metabolism
The microbial metabolite trimethylamine (TMA), the precursor of TMAO, which is associated with adverse cardiometabolic outcomes, is shown to have beneficial metabolic and anti-inflammatory effects in the host in the context of obesity.
dlvr.it
January 13, 2026 at 6:08 PM
RESEARCH | J Chilloux, @marcedumas.bsky.social et al. (Imperial College London)
The microbial metabolite TMA (precursor of TMAO) has beneficial metabolic and anti-inflammatory effects🧪
The microbial metabolite TMA (precursor of TMAO) has beneficial metabolic and anti-inflammatory effects🧪
Trimethylamin-N-Oxid (TMAO) ist übrigens geruchlos, während Trimethylamin (TMA) fischig riecht.
TMA reagiert mit Säuren zu Salzen (Ammoniumverbindungen), die auch geruchlos sind.
Deshalb träufelt man Zitronensäure auf Fisch, oder tunkt seine Finger in Zitronensaft, wenn man Krebse oder Krabben isst.
TMA reagiert mit Säuren zu Salzen (Ammoniumverbindungen), die auch geruchlos sind.
Deshalb träufelt man Zitronensäure auf Fisch, oder tunkt seine Finger in Zitronensaft, wenn man Krebse oder Krabben isst.
May 3, 2026 at 3:12 PM
Trimethylamin-N-Oxid (TMAO) ist übrigens geruchlos, während Trimethylamin (TMA) fischig riecht.
TMA reagiert mit Säuren zu Salzen (Ammoniumverbindungen), die auch geruchlos sind.
Deshalb träufelt man Zitronensäure auf Fisch, oder tunkt seine Finger in Zitronensaft, wenn man Krebse oder Krabben isst.
TMA reagiert mit Säuren zu Salzen (Ammoniumverbindungen), die auch geruchlos sind.
Deshalb träufelt man Zitronensäure auf Fisch, oder tunkt seine Finger in Zitronensaft, wenn man Krebse oder Krabben isst.
800m
C’est ici que l’on croise le Requin du Groenland. Ce colosse peut vivre jusqu'à 400, voire 500 ans. Son secret ? Un métabolisme extrêmement lent et une substance protectrice contre la pression : le TMAO.
C’est ici que l’on croise le Requin du Groenland. Ce colosse peut vivre jusqu'à 400, voire 500 ans. Son secret ? Un métabolisme extrêmement lent et une substance protectrice contre la pression : le TMAO.
July 2, 2026 at 8:03 AM
800m
C’est ici que l’on croise le Requin du Groenland. Ce colosse peut vivre jusqu'à 400, voire 500 ans. Son secret ? Un métabolisme extrêmement lent et une substance protectrice contre la pression : le TMAO.
C’est ici que l’on croise le Requin du Groenland. Ce colosse peut vivre jusqu'à 400, voire 500 ans. Son secret ? Un métabolisme extrêmement lent et une substance protectrice contre la pression : le TMAO.
ha, crtica ovamo, crtica tmao, u velebnoj republici hrvatskoj ima svijeta koji zarađuje prevodeći sa srpskog, a ujevića i krležu "lektoriraju" da ne zvuče srpski
August 19, 2026 at 6:17 PM
ha, crtica ovamo, crtica tmao, u velebnoj republici hrvatskoj ima svijeta koji zarađuje prevodeći sa srpskog, a ujevića i krležu "lektoriraju" da ne zvuče srpski
Red meat might raise your risk of abdominal aortic aneurysm, says a new Cleveland Clinic study. The link? A compound called TMAO.
Read more: www.pcrm.org/news/health-...
Read more: www.pcrm.org/news/health-...
August 29, 2025 at 4:46 PM
Red meat might raise your risk of abdominal aortic aneurysm, says a new Cleveland Clinic study. The link? A compound called TMAO.
Read more: www.pcrm.org/news/health-...
Read more: www.pcrm.org/news/health-...
[2/3] Pour survivre, ces poissons produisent du TMAO, une molécule qui stabilise les protéines et renforce les membranes cellulaires face à la pression. Plus on descend, plus la concentration de TMAO augmente, montrant un lien direct entre adaptation biologique et profondeur. #geography #deepsea
September 21, 2025 at 6:51 AM
[2/3] Pour survivre, ces poissons produisent du TMAO, une molécule qui stabilise les protéines et renforce les membranes cellulaires face à la pression. Plus on descend, plus la concentration de TMAO augmente, montrant un lien direct entre adaptation biologique et profondeur. #geography #deepsea
Gut–heart–brain links in heart failure: microbial dysbiosis and metabolites like TMAO connect cardiac and cognitive decline, pointing to the microbiome as a new therapeutic frontier. #HeartFailure #Microbiome www.mdpi.com/2075-4426/15...
February 8, 2026 at 11:31 AM
Gut–heart–brain links in heart failure: microbial dysbiosis and metabolites like TMAO connect cardiac and cognitive decline, pointing to the microbiome as a new therapeutic frontier. #HeartFailure #Microbiome www.mdpi.com/2075-4426/15...
Replacing red meat with plant-sourced products may lead to a more favorable metabolic risk profile: doi.org/10.1038/s415... #Health #Nutrition #PlantBased #Diets #Meat
Processed plant-based meat-supplemented diet versus red meat-based supplemented diet randomized cross-over trial Finding Optimal Oral Diet-1 (FOOD-1) trial - Scientific Reports
Serum Trimethylamine N-oxide (TMAO) is heightened by red-meat rich diets and associated with increased cardiovascular risk. Replacing red-meat with plant-based sources may reduce TMAO levels. FOOD-1 i...
doi.org
March 14, 2026 at 2:49 PM
Replacing red meat with plant-sourced products may lead to a more favorable metabolic risk profile: doi.org/10.1038/s415... #Health #Nutrition #PlantBased #Diets #Meat
Elevated TMAO levels linked to higher diabetes risk, study finds 🍽️🩺🔬 www.news-medical.net/news/2024060... #Diabetes #TMAO #Type2Diabetes #GutMicrobiota #Nutrition #Science #DiabetesPrevention #Health #Diet #MetabolicHealth #PublicHealth
Elevated TMAO levels linked to higher diabetes risk, study finds
A recent Nutrients study links elevated trimethylamine N-oxide (TMAO) levels with an increased risk of type 2 diabetes, highlighting the role of diet in diabetes prevention.
www.news-medical.net
June 5, 2024 at 12:53 AM
Elevated TMAO levels linked to higher diabetes risk, study finds 🍽️🩺🔬 www.news-medical.net/news/2024060... #Diabetes #TMAO #Type2Diabetes #GutMicrobiota #Nutrition #Science #DiabetesPrevention #Health #Diet #MetabolicHealth #PublicHealth
It's healthier than red meat (mammals) in that it is *very* well established that health problems fm high blood pressure to diabetes are associated with consumption of beef, pork etc & related fats. (Especially via TMAO & Neu5gc.) So to the extent meat substitutes are *not* that, they are healthier.
September 3, 2024 at 6:47 PM
It's healthier than red meat (mammals) in that it is *very* well established that health problems fm high blood pressure to diabetes are associated with consumption of beef, pork etc & related fats. (Especially via TMAO & Neu5gc.) So to the extent meat substitutes are *not* that, they are healthier.
PRMT5 methylates NF-κB p65 to enhance trimethylamine N-oxide-NOX4-induced #SmoothMuscleCell inflammation
SM22α+ SMC PRMT5 KO🐭 + carotid wire injury + TMAO i.p.▶️
⏬p65 methylation
⏬Vascular cell VCAM1
⏬CD68 recruitment
#CellDeathDis 2022
www.nature.com/articles/s41...
SM22α+ SMC PRMT5 KO🐭 + carotid wire injury + TMAO i.p.▶️
⏬p65 methylation
⏬Vascular cell VCAM1
⏬CD68 recruitment
#CellDeathDis 2022
www.nature.com/articles/s41...
November 17, 2025 at 8:04 PM
PRMT5 methylates NF-κB p65 to enhance trimethylamine N-oxide-NOX4-induced #SmoothMuscleCell inflammation
SM22α+ SMC PRMT5 KO🐭 + carotid wire injury + TMAO i.p.▶️
⏬p65 methylation
⏬Vascular cell VCAM1
⏬CD68 recruitment
#CellDeathDis 2022
www.nature.com/articles/s41...
SM22α+ SMC PRMT5 KO🐭 + carotid wire injury + TMAO i.p.▶️
⏬p65 methylation
⏬Vascular cell VCAM1
⏬CD68 recruitment
#CellDeathDis 2022
www.nature.com/articles/s41...
Also, huge molarity of trimethylamine N-oxide (TMAO). Like, tasty stuff!
January 7, 2026 at 4:11 PM
Also, huge molarity of trimethylamine N-oxide (TMAO). Like, tasty stuff!
🎧 Listen to our #PressRelease on the #Research paper, "TMAO is associated with higher age, cardiometabolic risk factors and degenerative alterations of the brain in healthy elderly adults."
https://bit.ly/4xu8ov4
#Aging #Podcast #Audio #SoundCloud #PaperSpotlight #OA
https://bit.ly/4xu8ov4
#Aging #Podcast #Audio #SoundCloud #PaperSpotlight #OA
Higher TMAO Levels Linked to Cardiometabolic Risk and Brain Atrophy in Older Adults
BUFFALO, NY — August 31, 2026 — A new research paper was published in Volume 18 of Aging on August 11, 2026, titled “TMAO is associated with higher age, cardiometabolic risk factors and degenerative a
soundcloud.com
August 31, 2026 at 8:00 PM
🎧 Listen to our #PressRelease on the #Research paper, "TMAO is associated with higher age, cardiometabolic risk factors and degenerative alterations of the brain in healthy elderly adults."
https://bit.ly/4xu8ov4
#Aging #Podcast #Audio #SoundCloud #PaperSpotlight #OA
https://bit.ly/4xu8ov4
#Aging #Podcast #Audio #SoundCloud #PaperSpotlight #OA
In patients with chronic kidney disease you see high circulating levels of 3 microbiome-associated metabolites: indoxyl sulfate, TMAO and p-cresol sulfate (pCS). We'd looked at all, but found pCS damaged the blood-brain barrier in vitro, and had a long-lasting effect in vivo.
Delighted to see this out, after a 2-year-long review process that left @drsimonmcarthur.bsky.social and I wondering what we'd done to upset the reviewing gods. #microbiomesky #gutbrainaxis www.tandfonline.com/doi/full/10....
Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor
The gut microbiota-brain axis has been associated with the pathogenesis of numerous disorders, but the mechanism(s) underlying these links are generally poorly understood. Accumulating evidence ind...
www.tandfonline.com
November 25, 2024 at 8:58 AM
In patients with chronic kidney disease you see high circulating levels of 3 microbiome-associated metabolites: indoxyl sulfate, TMAO and p-cresol sulfate (pCS). We'd looked at all, but found pCS damaged the blood-brain barrier in vitro, and had a long-lasting effect in vivo.
New study: "In summary, this study provides new evidence for the role of foodborne metabolites, TMA and TMAO, in CRC." #cansky #oncsky #oncology #medsky #colorectalcancer #coloncancer #TMAO #microbiome #eggs #redmeat
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 6, 2025 at 6:52 PM
New study: "In summary, this study provides new evidence for the role of foodborne metabolites, TMA and TMAO, in CRC." #cansky #oncsky #oncology #medsky #colorectalcancer #coloncancer #TMAO #microbiome #eggs #redmeat
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Snailfish are also the deepest known #fish :) The deep sea snailfish have almost entirely gelatinos bodies, very few rigid bones, and they produce a protein called trimethylamine N-oxide (TMAO) which protects their cells from the insane pressure at the bottom of the mariana trench :D
Snailfishes live in a variety of ocean habitats—from shallow tide pools to deep-sea trenches. The newly described bumpy snailfish (Careproctus colliculi), observed in the depths of Monterey Canyon nearly 3,300 meters (10,800 feet) underwater, has a distinctive pink color and a bumpy texture.
October 23, 2025 at 2:06 AM
Snailfish are also the deepest known #fish :) The deep sea snailfish have almost entirely gelatinos bodies, very few rigid bones, and they produce a protein called trimethylamine N-oxide (TMAO) which protects their cells from the insane pressure at the bottom of the mariana trench :D
TMAO, red meat causes inflammation, red meat increased insulin resistance..
Walter! Willett ever end?!
Walter! Willett ever end?!
January 28, 2025 at 9:38 PM
TMAO, red meat causes inflammation, red meat increased insulin resistance..
Walter! Willett ever end?!
Walter! Willett ever end?!
A pilot and feasibility analysis of serum TMAO and choline in a randomized sample from the COSMOS trial #FoodFunct #MassSpec pubs.rsc.org/en/content/a...
A pilot and feasibility analysis of serum TMAO and choline in a randomized sample from the COSMOS trial
Objective: The metabolite trimethylamine N-oxide (TMAO) is a biomarker influenced by diet and linked to atherosclerosis, thrombosis, and cardiovascular disease (CVD). Choline is a crucial nutrient inv...
pubs.rsc.org
October 23, 2025 at 6:18 PM
A pilot and feasibility analysis of serum TMAO and choline in a randomized sample from the COSMOS trial #FoodFunct #MassSpec pubs.rsc.org/en/content/a...
TMAO is a major component of fish. It protected against effects of mercury (a common environmental contaminant of fish) in our in vitro model.
/5
/5
July 6, 2026 at 4:59 PM
TMAO is a major component of fish. It protected against effects of mercury (a common environmental contaminant of fish) in our in vitro model.
/5
/5
🦠Your diet shapes your gut microbiome—& your heart.
Gut microbiota-derived metabolites like SCFAs, TMAO, PAGln, and LPS play key roles in vascular health, influencing atherosclerosis, thrombosis, aneurysm, and hypertension.
#GutMicrobiome #Microbiome #CardiovascularHealth #TMAO #PrecisionMedicine
Gut microbiota-derived metabolites like SCFAs, TMAO, PAGln, and LPS play key roles in vascular health, influencing atherosclerosis, thrombosis, aneurysm, and hypertension.
#GutMicrobiome #Microbiome #CardiovascularHealth #TMAO #PrecisionMedicine
July 16, 2026 at 5:30 AM
🦠Your diet shapes your gut microbiome—& your heart.
Gut microbiota-derived metabolites like SCFAs, TMAO, PAGln, and LPS play key roles in vascular health, influencing atherosclerosis, thrombosis, aneurysm, and hypertension.
#GutMicrobiome #Microbiome #CardiovascularHealth #TMAO #PrecisionMedicine
Gut microbiota-derived metabolites like SCFAs, TMAO, PAGln, and LPS play key roles in vascular health, influencing atherosclerosis, thrombosis, aneurysm, and hypertension.
#GutMicrobiome #Microbiome #CardiovascularHealth #TMAO #PrecisionMedicine