#Medsky🧪 #IDsky #Immunosky #publichealth #Vaccines generate long-lived plasma cells & #memoryBcells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell receptor upon 💉& re-exposure to antigen.
Recap
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Recap
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Memory B cells - Nature Reviews Immunology
Memory B cells are critical for protection against repeated infections, particularly with viral variants, and understanding their function and development is key for successful vaccine development. Th...
www.nature.com
July 2, 2025 at 1:48 AM
This week in #Science #Immunology: a fantastic paper on #GerminalCenter #BCell #immunometabolism! Check it out!
This week in #ScienceImmunology: Germinal Center B cells require asparagine (Asn) #metabolism for their function. GC B cells can acquire exogenous Asn from their local environment, but when Asn is limited, they utilise the enzyme asparginine synthetase. @ajclarke.bsky.social @yfy1.bsky.social
Asparagine availability controls germinal center B cell homeostasis
Asparagine metabolism is a critical regulator of germinal center B cell function.
www.science.org
December 14, 2024 at 3:59 PM
This week in #Science #Immunology: a fantastic paper on #GerminalCenter #BCell #immunometabolism! Check it out!
Besides wiping out the memory Bcell repertoire
April 21, 2026 at 2:05 PM
Besides wiping out the memory Bcell repertoire
Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling
Ogishi, Kitaoka, et al. examine humans deficient in PD-1 and PD-L1 as well as associated
mouse models and find that PD-1 and PD-L1 promote B cell memory and antibody responses
through both T cell-depe...
www.cell.com
November 26, 2024 at 8:34 PM
#Medsky🧪 #IDsky #immunosky #Casereport identified a case of very #longCOVID caused by impaired #Bcell –mediated #immunity to #SARSCoV2 in a patient with #Goodsyndrome. Immunoglobulin replacement therapy alone was sufficient to achieve clinical & radiological resolution.
Good? A very long #COVID19. A new case report from Quentin Philippot and colleagues @upcite.bsky.social: rupress.org/jhi/article/...
#SARSCoV2
#SARSCoV2
January 25, 2026 at 9:41 PM
#Medsky🧪 #IDsky #immunosky #Casereport identified a case of very #longCOVID caused by impaired #Bcell –mediated #immunity to #SARSCoV2 in a patient with #Goodsyndrome. Immunoglobulin replacement therapy alone was sufficient to achieve clinical & radiological resolution.
#Medsky #IDSky #virosky #immunosky #publichealth
A recent #clinicaltrial demonstrated that the PHH-1V81 XBB.1.16-adapted #COVID booster 💉 induced robust , coordinated #antibody & #Bcell responses in previously vaccinated adults.
A recent #clinicaltrial demonstrated that the PHH-1V81 XBB.1.16-adapted #COVID booster 💉 induced robust , coordinated #antibody & #Bcell responses in previously vaccinated adults.
September 1, 2025 at 4:06 PM
#Medsky #IDSky #virosky #immunosky #publichealth
A recent #clinicaltrial demonstrated that the PHH-1V81 XBB.1.16-adapted #COVID booster 💉 induced robust , coordinated #antibody & #Bcell responses in previously vaccinated adults.
A recent #clinicaltrial demonstrated that the PHH-1V81 XBB.1.16-adapted #COVID booster 💉 induced robust , coordinated #antibody & #Bcell responses in previously vaccinated adults.
Our long-awaited study in collaboration with the Schmidt lab on H5Nx influenza recognition by naive B cells is out! #antibody #bcell #flu #avianflu #cryoEM
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Human naïve B cells recognize prepandemic influenza virus hemagglutinins
Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.
www.science.org
January 24, 2025 at 10:06 PM
Researchers in #ScienceTranslationalMedicine find a distinct #Bcell and antibody profile in infants and mothers in an Older Order Mennonite farming community, associated with lower incidence of egg #allergy. https://scim.ag/48rPBGS
Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy
Infants from a traditional farming community exhibited antibody profiles that were found to be associated with lower incidence of egg allergy.
scim.ag
December 15, 2025 at 7:12 PM
Researchers in #ScienceTranslationalMedicine find a distinct #Bcell and antibody profile in infants and mothers in an Older Order Mennonite farming community, associated with lower incidence of egg #allergy. https://scim.ag/48rPBGS
Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue.
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination | PNAS
The nasal mucosa is the first immunologically active site that respiratory viruses
encounter and establishing immunity at the initial point of path...
www.pnas.org
March 25, 2025 at 10:28 AM
Our latest study by PhD student #RomainGailleton shows that upon #influenza infection, #Bcell can respond rapidly by forming ectopic #GerminalCenter within the nasal tissue.
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
The work has just been published in @pnas.org (1/N)
www.pnas.org/doi/10.1073/...
Really timely work on naive #BCell recognition of #H5Nx #influenza ( #BirdFlu ) from the @gogo-science.bsky.social & Schmidt labs out now in #Science #Immunology! Check it out!
In #Science #Immunology this week: human naïve B cells can bind and neutralize #H5N1, potentially offering protection against #birdflu.
Human naïve B cells recognize prepandemic influenza virus hemagglutinins
Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.
www.science.org
January 28, 2025 at 4:26 PM
Really timely work on naive #BCell recognition of #H5Nx #influenza ( #BirdFlu ) from the @gogo-science.bsky.social & Schmidt labs out now in #Science #Immunology! Check it out!
#Medsky🧪 #IDsky #immunosky #publichealth
Highlights
• #COVID19vaccination induces durable & #Bcell responses in exposed and naive humans
• Spike+ B cells gradually expand toward the recognition of the RBD subdomain
Highlights
• #COVID19vaccination induces durable & #Bcell responses in exposed and naive humans
• Spike+ B cells gradually expand toward the recognition of the RBD subdomain
July 13, 2025 at 6:02 AM
#Medsky🧪 #IDsky #immunosky #publichealth
Highlights
• #COVID19vaccination induces durable & #Bcell responses in exposed and naive humans
• Spike+ B cells gradually expand toward the recognition of the RBD subdomain
Highlights
• #COVID19vaccination induces durable & #Bcell responses in exposed and naive humans
• Spike+ B cells gradually expand toward the recognition of the RBD subdomain
April 12, 2025 at 10:31 AM
Have your students act out an immune response with our Immune System paper model! Give them prizes for best sound effects! Learn more here: bit.ly/2QUGerF
#EduSky #iteachbio #immunesystem #Tcell #Bcell #immuneresponse
#EduSky #iteachbio #immunesystem #Tcell #Bcell #immuneresponse
April 3, 2025 at 7:02 PM
Have your students act out an immune response with our Immune System paper model! Give them prizes for best sound effects! Learn more here: bit.ly/2QUGerF
#EduSky #iteachbio #immunesystem #Tcell #Bcell #immuneresponse
#EduSky #iteachbio #immunesystem #Tcell #Bcell #immuneresponse
#MedSky🧪 #IDSky #pedsky #publichealth Recaps to the end 2024.
Given that children possess high #Bcell percentages & highly diverse #Bcell clonotypes, infection with a newly circulating viral strain following
www.nature.com/articles/s41...
api.repository.cam.ac.uk/server/api/c...
Given that children possess high #Bcell percentages & highly diverse #Bcell clonotypes, infection with a newly circulating viral strain following
www.nature.com/articles/s41...
api.repository.cam.ac.uk/server/api/c...
December 31, 2024 at 7:00 AM
#MedSky🧪 #IDSky #pedsky #publichealth Recaps to the end 2024.
Given that children possess high #Bcell percentages & highly diverse #Bcell clonotypes, infection with a newly circulating viral strain following
www.nature.com/articles/s41...
api.repository.cam.ac.uk/server/api/c...
Given that children possess high #Bcell percentages & highly diverse #Bcell clonotypes, infection with a newly circulating viral strain following
www.nature.com/articles/s41...
api.repository.cam.ac.uk/server/api/c...
How to write a perfect Keystone Abstract:
Start with
-real fireplace
-caponata (so good) and calamari (so fried)
-did you say wine?
The end.
#Keystone
#Bcell
#Montecarlo
Start with
-real fireplace
-caponata (so good) and calamari (so fried)
-did you say wine?
The end.
#Keystone
#Bcell
#Montecarlo
November 18, 2024 at 12:27 AM
How to write a perfect Keystone Abstract:
Start with
-real fireplace
-caponata (so good) and calamari (so fried)
-did you say wine?
The end.
#Keystone
#Bcell
#Montecarlo
Start with
-real fireplace
-caponata (so good) and calamari (so fried)
-did you say wine?
The end.
#Keystone
#Bcell
#Montecarlo
MedSky🧪These results demonstrate that serial #Covid19vaccination strategies can be effective for a subset of #Bcell–depleted patients.
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
August 31, 2023 at 8:02 PM
MedSky🧪These results demonstrate that serial #Covid19vaccination strategies can be effective for a subset of #Bcell–depleted patients.
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
#Medsky🧪 #IDsky #immunosky #virosky #Publichealth Based on a study in @sciimmunology.bsky.social , a #covid booster immunization drives a germinal center mediated broadening of #Bcell responses by recalling existing #memoryBcells
October 10, 2025 at 8:00 PM
#Medsky🧪 #IDsky #immunosky #virosky #Publichealth Based on a study in @sciimmunology.bsky.social , a #covid booster immunization drives a germinal center mediated broadening of #Bcell responses by recalling existing #memoryBcells
📣Call out to #bcell enthusiasts!
#EFIS IL-Study Group European B cell Network is happy to invite you to their Satellite Symposium at the #IUIS2025.
Don't miss the opportunity to listen to brilliant speakers highlighting the recent advances in #Bcellbiology.
@yefis-immunology.bsky.social
#EFIS IL-Study Group European B cell Network is happy to invite you to their Satellite Symposium at the #IUIS2025.
Don't miss the opportunity to listen to brilliant speakers highlighting the recent advances in #Bcellbiology.
@yefis-immunology.bsky.social
June 25, 2025 at 10:43 AM
📣Call out to #bcell enthusiasts!
#EFIS IL-Study Group European B cell Network is happy to invite you to their Satellite Symposium at the #IUIS2025.
Don't miss the opportunity to listen to brilliant speakers highlighting the recent advances in #Bcellbiology.
@yefis-immunology.bsky.social
#EFIS IL-Study Group European B cell Network is happy to invite you to their Satellite Symposium at the #IUIS2025.
Don't miss the opportunity to listen to brilliant speakers highlighting the recent advances in #Bcellbiology.
@yefis-immunology.bsky.social
December 18, 2024 at 5:04 PM
#Medsky🧪 #IDsky #immunosky #oncosky #publichealth Among ICHs, those with #hematologicmalignancies, particularly #Bcell malignancies and those receiving B-cell depletingtherapies, as #monoclonal antibodies (mAbs) targeting the CD20 #antigen (anti-CD20)
September 9, 2025 at 6:31 AM
#Medsky🧪 #IDsky #immunosky #oncosky #publichealth Among ICHs, those with #hematologicmalignancies, particularly #Bcell malignancies and those receiving B-cell depletingtherapies, as #monoclonal antibodies (mAbs) targeting the CD20 #antigen (anti-CD20)
B cell depletion targeting CD19 trial in ME/CFS and PCS
There is a strong rationale for Bcell depletion in post infectious autoimmune #MyalgicEncephalomyelitis
We should target modern Bcell cd19/20 therapy
Those that repost serious infection get IG
Judith Bellmann-Strobl
#MECFSConference2025
There is a strong rationale for Bcell depletion in post infectious autoimmune #MyalgicEncephalomyelitis
We should target modern Bcell cd19/20 therapy
Those that repost serious infection get IG
Judith Bellmann-Strobl
#MECFSConference2025
May 13, 2025 at 8:02 AM
B cell depletion targeting CD19 trial in ME/CFS and PCS
There is a strong rationale for Bcell depletion in post infectious autoimmune #MyalgicEncephalomyelitis
We should target modern Bcell cd19/20 therapy
Those that repost serious infection get IG
Judith Bellmann-Strobl
#MECFSConference2025
There is a strong rationale for Bcell depletion in post infectious autoimmune #MyalgicEncephalomyelitis
We should target modern Bcell cd19/20 therapy
Those that repost serious infection get IG
Judith Bellmann-Strobl
#MECFSConference2025