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grrlscientist.bsky.social
An Eight-Week Vegan Diet May Slow Biological Aging, study out of Stanford University, published by BMC Medicine

by @GrrlScientist

#GoVegan🥕 #HealthyEating🌶️ #foods🫘 #Twins #Aging #EpigeneticClock #SciComm🧪 www.forbes.com/sites/grrlsc...
July 30, 2024 at 3:01 PM
niooknaw.bsky.social
New publication: Independent avian epigenetic clocks for ageing and development, by @keesvanoers.bsky.social and others. #epigenetics #epigeneticclock #parusmajor #ageing #DNAmethylation
doi.org/10.1111/1755...
doi.org
June 13, 2025 at 8:34 AM
cramideas.bsky.social
How old are you really? Find out what your
biological age is! #GRYMclock #ageing #epigenetics #chronologicalage #epigeneticclock #Genetics #ScienceOfAging #HealthAndWellness #HealthyAging #HealthFacts #Podcast #PodcastEpisode
September 4, 2025 at 3:10 AM
alicefrolov.bsky.social
Epigenetic age reversal kinetics under partial versus complete Yamanaka factor-mediated reprogramming

Transient induction of OCT4, SOX2, and KLF4 (OSK) or the complete OSKM cassette.

#EpigeneticReprogramming #YamanakaFactors #PartialReprogramming #EpigeneticClock #OSK #Rejuvenation #AgingBiology
Epigenetic age reversal kinetics under partial versus complete Yamanaka factor-mediated reprogramming Transient induction of OCT4, SOX2, and KLF4 (OSK) — or the complete OSKM cassette — drives progressive erasure of age-associated epigenetic marks, quantifiable via Horvath-family methylation clocks as negative delta biological age. Partial reprogramming protocols, defined by abbreviated factor expression prior to loss of somatic identity, achieve significant epigenetic rejuvenation while preserving cell-type-specific transcriptional programs — a critical distinction from complete reprogramming, which traverses a pluripotent intermediate with associated risks of teratoma formation and epigenetic dysregulation. The dose-response relationship between reprogramming cycle number and clock-measured age reversal suggests saturable resetting of methylation at clock CpGs, with diminishing returns beyond a tissue-specific threshold. Mechanistically, OSK-mediated rejuvenation is proposed to operate through TET-dependent active demethylation at age-hypermethylated loci and restoration of H3K27me3 patterning at Polycomb targets — implicating chromatin remodeling upstream of transcriptional identity restoration. These findings position partial reprogramming as the most mechanistically proximate intervention to date for reversing the epigenetic component of cellular aging.
May 29, 2026 at 5:00 PM
newsmedical.bsky.social
CheekAge: Next-gen epigenetic clock accurately predicts mortality risk 🔬🧬📊 www.news-medical.net/news/2024100... #aging #epigenetics #longevity #methylation #mortalityrisk #healthspan #genomics #epigeneticclock #biomarkers #buccalcells
CheekAge: Next-gen epigenetic clock accurately predicts mortality risk
Researchers developed CheekAge, an epigenetic clock based on buccal cells, and found it predicted mortality risk with significant accuracy. This study validates CheekAge as a reliable aging biomarker,...
www.news-medical.net
October 6, 2024 at 11:43 PM
healthday.bsky.social
Using advanced biological aging clocks, researchers measured aging in 17 organ systems and found too little or too much sleep impacts the brain, heart, lungs, and more.

youtu.be/h4kg_zmTQBI

#SleepScience #BiologicalAging #EpigeneticClock #SleepAndHealth #SleepDeprivation
Too Little or Too Much Sleep Ages Every Organ in Your Body
YouTube video by HealthDay
youtu.be
May 16, 2026 at 5:56 PM
tonnyjohnson.bsky.social
Can Lifestyle Rewire Biological Aging? Insights From Epigenetic Clocks and New Evidence From Frailty Research
Link to our article: www.marinbio.com/can-lifestyl...
#aging #epigenetics #antiaging #epigeneticclock #frailty
Can Lifestyle Rewire Biological Aging? Insights From Epigenetic Clocks and New Evidence From Frailty Research
Aging is increasingly recognized as a biologically dynamic process influenced by environmental and behavioral factors rather than solely by chronological time. Frailty, a multidimensional syndrome of ...
www.marinbio.com
February 14, 2026 at 3:11 AM
americanaging.bsky.social
New Nature Aging study: it's not just your epigenetic age that predicts survival — it's how fast it's changing. Accelerating biological age = higher mortality risk, regardless of starting point 🧬⏱️
#EpigeneticClock #Longevity #AgingResearch
July 16, 2026 at 10:30 PM
americanaging.bsky.social
New Nature Aging study: it's not just your epigenetic age that predicts survival — it's how fast it's changing over time.

Accelerating biological age = higher mortality risk, regardless of starting point 🧬⏱️
www.nature.com/articles/s43...

#EpigeneticClock #BiologicalAge #Longevity
July 7, 2026 at 4:31 PM
robertlufkinmd.bsky.social
#Longevity #Healthspan #ForeverYoung #EpigeneticClock #HealthLongevitySecrets (8/8)
May 30, 2026 at 12:43 PM
robertlufkinmd.bsky.social
As a medical school professor, I read every "reverse aging" claim with a sharp eye. A 2024 vehicle-controlled topical study (DHM/Epicelline) shifted >95% ... https://www.youtube.com/@RobertLufkinMD

#SkinAging #EpigeneticClock #Longevity #Metabolism
https://pmc.ncbi.nlm.nih.gov/articles/PMC10944877/
May 6, 2026 at 12:23 PM
alicefrolov.bsky.social
NSD1/NSD2, H3K36me2, and chromatin domain boundaries in aging

Publication trend (PubMed, 2006–2026): a low, irregular baseline of 0–2 papers/year through 2017, a sharp jump to 5 in 2018.

#NSD1 #NSD2 #H3K36me2 #epigeneticclock #Polycomb #DNMT3A #SotosSyndrome.
Publication trend (PubMed, 2006–2026): a low, irregular baseline of 0–2 papers/year through 2017, a sharp jump to 5 in 2018, a dip to 2 in 2019, continued fluctuation in the 3–5 range, a peak of 6 papers in 2025, tapering slightly to 5 by 2026 (partial year). The most steadily growing of the four topics in recent years. Mechanism. NSD1 and NSD2 deposit H3K36me2 predominantly across intergenic genomic regions. This mark functions as an active barrier against the spread of repressive Polycomb (H3K27me3) and ectopic de novo DNA methylation. Genetic deletion of NSD1 in embryonic stem cells causes H3K27me3 to expand genome-wide, including into regions beyond the original PRC2 target loci — meaning H3K36me2 doesn't just mark active chromatin, it actively maintains the boundaries between chromatin domains. Upon NSD1/NSD2 loss in mesenchymal stem cells, DNMT3A — normally recruited to H3K36me2-enriched intergenic regions — is redirected toward gene bodies enriched in H3K36me3, disrupting the normal genome-wide distribution of DNA methylation, not merely removing one mark in isolation. The link to age-related epigenetic drift is clinically established, not hypothetical. Loss-of-function NSD1 mutations causing Sotos syndrome substantially accelerate the Horvath epigenetic clock in patients, and the methylation pattern in this syndrome partially overlaps with the pattern of normal chronological aging. Separately, in an accelerated-aging mouse model (SAMP8 strain), reduced H3K36me3 has been observed in brain tissue compared to wild-type controls. A systematic knockout of all five H3K36 methyltransferases (SETD2, NSD1, NSD2, NSD3, ASH1L) shows that loss of H3K36me2/3 triggers not only H3K27me3 expansion but also redistribution of large H3K9me3 heterochromatic domains into euchromatin (partly via SUV39H1), with a collapse of 3D genome organization — meaning erosion of one mark cascades across multiple heterochromatin systems at once.
June 24, 2026 at 5:00 PM
christianlthomas.bsky.social
Our lab have extended our previous findings of an epigenetic clock in insect species by showing the epigenetjc clock is plastic. As diapause increases adult lifespan, we see a slowing of the epigenetic clock! Preprint:

#Diapause #Nasonia #Epigenetic #EpigeneticClock

www.biorxiv.org/content/10.1...
Larval diapause slows adult epigenetic ageing in an insect model, Nasonia vitripennis
Epigenetic clocks based on DNA methylation provide robust biomarkers of biological age, yet the mechanistic basis and functional significance of slowing these clocks remain unclear. Progress has been ...
www.biorxiv.org
May 25, 2025 at 7:19 AM
aging-us.bsky.social
🎥 #AgingShort:
Abstract #video about this #research paper, titled "Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer."

www.youtube.com/watch?v=cq1M...

#aging #colorectalcancer #DNAMethylation #epigeneticclock #diet #openaccess #publishing
Epigenetic Age and Accelerated Aging Phenotypes in Colorectal Cancer | Aging-US
YouTube video by Aging (Aging-US)
www.youtube.com
August 18, 2025 at 6:05 PM
aging-us.bsky.social
🔆 #PaperSpotlight:
A new #research perspective was #published on July 8 in Volume 17, Issue 7, titled “Exercise as a geroprotector: focusing on epigenetic aging.”

🔗 doi.org/10.18632/aging.206278

#aging #quote #exercise #fitness #epigeneticclock #perspective #oa #publishing #peerreviewed #journal
Exercise as a geroprotector: focusing on epigenetic aging
August 12, 2025 at 4:05 PM
aging-us.bsky.social
🎧 Listen to our #pressrelease about the #research perspective, "Exercise as a geroprotector: focusing on epigenetic aging."

soundcloud.com/aging-us/exe...

#aging #podcast #audio #soundcloud #exercise #fitness #epigeneticclock #perspective #paperspotlight #oa #publishing #press
Exercise May Slow Epigenetic Aging
BUFFALO, NY — August 12, 2025 — A new #research perspective was #published in Aging (Aging-US) on July 8, 2025, titled “Exercise as a geroprotector: focusing on epigenetic aging.” In this perspective
soundcloud.com
August 12, 2025 at 10:43 AM
aging-us.bsky.social
🔆 #PaperSpotlight:
This #research perspective was #published in Volume 17, Issue 7, titled "Exercise as a geroprotector: focusing on epigenetic aging."

#PressRelease ⬇️
www.aging-us.com/news-room/ex...

#aging #exercise #fitness #epigeneticclock #perspective #press #oa #publishing
Exercise May Slow Epigenetic Aging... | Aging
Collectively, these findings suggest that increased leisure-time physical activity and reduced sedentary behavior may have beneficial effects on epigenetic aging."Click here to listen to the pres...
www.aging-us.com
August 12, 2025 at 10:43 AM
tonnyjohnson.bsky.social
From Resilience to Epigenetic Clocks: How Childhood Resilience Could Slow Biological Aging
www.marinbio.com/from-resilie...
#aging #epigeneticclock #epigeneticd #biologicalaging
From Resilience to Epigenetic Clocks: How Childhood Resilience Could Slow Biological Aging - Marin Biologic Laboratories
Researchers from the University of Helsinki and Tampere University in Finland have made a groundbreaking discovery linking childhood resilience to biological aging in adulthood. The study, part of the...
www.marinbio.com
November 19, 2024 at 8:25 AM