Milenkovic et al. demonstrate that rRNA modifications are differentially modified across tissues, developmental stages, and in disease. The authors show that rRNA modification patterns, also termed “epitranscriptomic rRNA fingerprints,” are sufficient to accurately identify tissue of origin and tumorigenicity, from as few as 250 reads.

Here, we review epitranscriptomic regulation of Notch signaling, focusing on RNA modification-dependent control of the processing, localization, stability, translation, and editing of Notch-related transcripts.

Abstract. The impacts of various stressors on bacterial systems have been studied at the phenotypic, transcriptional, and translational levels during the e

Direct RNA-seq in brain reveals RNA isoform and region-specific m6A modifications, highlighting their role in gene regulation.

Direct RNA sequencing (DRS) enables systematic profiling of RNA modifications at an unprecedented resolution. Here, Diensthuber and Novoa review key efforts made to date pioneering the use of DRS for ...

RNA modifications dynamically regulate cancer hallmarks. Deng et al. summarize how epitranscriptomic marks (e.g., m6A, m5C, Ψ, and A-to-I editing) orchestrate tumor proliferation, stemness, metabolism, immune evasion, and therapy resistance. Emerging detection, single-cell mapping, and therapeutic targeting strategies position RNA epitranscriptomics as a new frontier in cancer biology and treatment.

Milenkovic et al. demonstrate that rRNA modifications are differentially modified across tissues, developmental stages, and in disease. The authors show that rRNA modification patterns, also termed “epitranscriptomic rRNA fingerprints,” are sufficient to accurately identify tissue of origin and tumorigenicity, from as few as 250 reads.

We developed FOCAS as a CRISPR-based platform enabling precise, high-throughput dissection of individual m6A sites across mRNA and carRNAs. It reveals RNA element-dependent m6A functions within genes, illuminating the context-dependent epitranscriptomic control of gene expression in cancer.

Abstract. The impacts of various stressors on bacterial systems have been studied at the phenotypic, transcriptional, and translational levels during the e

Author summary This study charts the first genome-wide map of transfer RNA (tRNA) modifications in the cholera pathogen, Vibrio cholerae, revealing how chemical marks on tRNAs shape translation and st...

Abstract. Post-transcriptional modification of transfer RNAs (tRNAs) represents an essential layer of translational regulation critical for bacterial adapt

Mammalian ribosomal RNA (rRNA) molecules are highly abundant RNAs, decorated with over 220 rRNA modifications. Previous works have shown that some rRN…

Nature Metabolism, Published online: 18 September 2026; doi:10.1038/s42255-026-01594-wThe epitranscriptomic mRNA modification N6-methyladenosine (m6A) helps to maintain the functional identity of pancreatic α-cells. Deletion of the m6A writer METTL14 impairs amino acid-stimulated glucagon secretion, destabilizes the α-cell state and promotes plasticity towards immature, insulin-secreting β-cell-like fates.