Although omega fatty acids are famous for their health benefits, new #ScienceSignaling experiments in mice show that some omega fatty acids can suppress the cancer-killing capabilities of natural killer cells by acting through a receptor named LRP5. https://scim.ag/4wObauU
LRP5-dependent transport of polyunsaturated fatty acids serves as an immune checkpoint for natural killer cells
Polyunsaturated fatty acids curb NK cell function and immunotherapy efficacy against colon cancer in mice.
scim.ag
August 12, 2026 at 3:00 PM
Although omega fatty acids are famous for their health benefits, new #ScienceSignaling experiments in mice show that some omega fatty acids can suppress the cancer-killing capabilities of natural killer cells by acting through a receptor named LRP5. https://scim.ag/4wObauU
Name: Zeya: The Ivory Idol
Age: 18
Height: 5'1
Country: Myanmar (Burma)
Fighting Style: Lethwei
Genetic Mutation: LRP5 gene (Unbreakable Bones)
#theartsofmars #oc #martialarts #lethwei #myanmar
Age: 18
Height: 5'1
Country: Myanmar (Burma)
Fighting Style: Lethwei
Genetic Mutation: LRP5 gene (Unbreakable Bones)
#theartsofmars #oc #martialarts #lethwei #myanmar
March 3, 2026 at 9:50 PM
Name: Zeya: The Ivory Idol
Age: 18
Height: 5'1
Country: Myanmar (Burma)
Fighting Style: Lethwei
Genetic Mutation: LRP5 gene (Unbreakable Bones)
#theartsofmars #oc #martialarts #lethwei #myanmar
Age: 18
Height: 5'1
Country: Myanmar (Burma)
Fighting Style: Lethwei
Genetic Mutation: LRP5 gene (Unbreakable Bones)
#theartsofmars #oc #martialarts #lethwei #myanmar
Development of the blood–brain barrier
👉Neural Progenitor-to-Endothelium
Wnt7a/7b-RECK-GPR124-FZD
Norrin-TSPAN12-LRP5/6-FZD4
👉Pericyte/Astrocyte-to-Endothelium
Angiotensin II
Angiopoietin 1
Shh
Circumventricular organ ❎BBB◀️WIF1
#Development 2026
journals.biologists.com/dev/article/...
👉Neural Progenitor-to-Endothelium
Wnt7a/7b-RECK-GPR124-FZD
Norrin-TSPAN12-LRP5/6-FZD4
👉Pericyte/Astrocyte-to-Endothelium
Angiotensin II
Angiopoietin 1
Shh
Circumventricular organ ❎BBB◀️WIF1
#Development 2026
journals.biologists.com/dev/article/...
January 26, 2026 at 12:49 PM
Development of the blood–brain barrier
👉Neural Progenitor-to-Endothelium
Wnt7a/7b-RECK-GPR124-FZD
Norrin-TSPAN12-LRP5/6-FZD4
👉Pericyte/Astrocyte-to-Endothelium
Angiotensin II
Angiopoietin 1
Shh
Circumventricular organ ❎BBB◀️WIF1
#Development 2026
journals.biologists.com/dev/article/...
👉Neural Progenitor-to-Endothelium
Wnt7a/7b-RECK-GPR124-FZD
Norrin-TSPAN12-LRP5/6-FZD4
👉Pericyte/Astrocyte-to-Endothelium
Angiotensin II
Angiopoietin 1
Shh
Circumventricular organ ❎BBB◀️WIF1
#Development 2026
journals.biologists.com/dev/article/...
Zeya the Ivory Idol (18) a up and coming fighter from Myanmar born with the LRP5 gene (Unbreakable Bones). Participate of the "Art of the nine limbs" Lethwei and it's intense training regime, made her bones three times more durable then ever. She's aggressive and violent nature.
#theartsofmars #oc
#theartsofmars #oc
March 2, 2026 at 2:52 AM
Zeya the Ivory Idol (18) a up and coming fighter from Myanmar born with the LRP5 gene (Unbreakable Bones). Participate of the "Art of the nine limbs" Lethwei and it's intense training regime, made her bones three times more durable then ever. She's aggressive and violent nature.
#theartsofmars #oc
#theartsofmars #oc
In the 2nd preprint from @mlodziklab.bsky.social, Weber et al. show that LRP5/6/arrow, the Wnt/bcatenin signaling specific co-receptor, is also required for Wnt/planar cell polarity establishment, a challenge and eye-opener for the Wnt field.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in Drosophila
Wnt-signaling, via β-catenin or the planar cell polarity (PCP) branch, is crucial for development, tissue homeostasis, and linked to many diseases. LRP5/6, arrow ( arr ) in Drosophila , is the obligat...
www.biorxiv.org
October 21, 2025 at 2:49 PM
In the 2nd preprint from @mlodziklab.bsky.social, Weber et al. show that LRP5/6/arrow, the Wnt/bcatenin signaling specific co-receptor, is also required for Wnt/planar cell polarity establishment, a challenge and eye-opener for the Wnt field.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 18, 2023 at 3:09 PM
Cassandra Diegel, @bartwilliams.bsky.social & co generated mice carrying an Lrp5 allele lacking the class A repeats and observed reduced bone mass and retinal vascularisation, suggesting an essential role for these repeats in normal #LRP5 function.
Read doi.org/10.1242/dmm....
Read doi.org/10.1242/dmm....
January 22, 2026 at 8:01 AM
Cassandra Diegel, @bartwilliams.bsky.social & co generated mice carrying an Lrp5 allele lacking the class A repeats and observed reduced bone mass and retinal vascularisation, suggesting an essential role for these repeats in normal #LRP5 function.
Read doi.org/10.1242/dmm....
Read doi.org/10.1242/dmm....
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
#Biochemistry #Trafficking #CellSignaling #Wnt
November 10, 2025 at 7:45 PM
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
#Biochemistry #Trafficking #CellSignaling #Wnt
These images show before and after treatment in the same eye of a retinal cystoid edema model
Here, Harald J. Junge & team introduce a cystoid edema mouse model, identify roles of C1q, and show that a FZD4/LRP5 agonist resolves cystoid edema: insight.jci.org/articles/vie...
Here, Harald J. Junge & team introduce a cystoid edema mouse model, identify roles of C1q, and show that a FZD4/LRP5 agonist resolves cystoid edema: insight.jci.org/articles/vie...
November 27, 2025 at 5:15 PM
These images show before and after treatment in the same eye of a retinal cystoid edema model
Here, Harald J. Junge & team introduce a cystoid edema mouse model, identify roles of C1q, and show that a FZD4/LRP5 agonist resolves cystoid edema: insight.jci.org/articles/vie...
Here, Harald J. Junge & team introduce a cystoid edema mouse model, identify roles of C1q, and show that a FZD4/LRP5 agonist resolves cystoid edema: insight.jci.org/articles/vie...
June 6, 2025 at 5:00 PM
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from Golgi to cell surface url: rupress.org/jcb/article-...
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from Golgi to cell surface
The authors demonstrate that B4GALT1 and WLS cooperate to retain the canonical Wnt receptor LRP5/6 on the Golgi apparatus, leading to specific inhibition o
rupress.org
November 3, 2025 at 3:25 PM
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from Golgi to cell surface url: rupress.org/jcb/article-...
Ce matin nous étions à Planoise Ile de France avec notre questionnaire.
Sous la pluie, mais rien ne nous arrête !
Les rencontres populaires continuent !
#municipales2026
#lrp5
Sous la pluie, mais rien ne nous arrête !
Les rencontres populaires continuent !
#municipales2026
#lrp5
June 7, 2025 at 3:52 PM
Ce matin nous étions à Planoise Ile de France avec notre questionnaire.
Sous la pluie, mais rien ne nous arrête !
Les rencontres populaires continuent !
#municipales2026
#lrp5
Sous la pluie, mais rien ne nous arrête !
Les rencontres populaires continuent !
#municipales2026
#lrp5
This study shows that #PsychologicalStress-induced #GutDysbiosis activates LRP5/β-catenin signaling, promoting #CancerStemness and tumor progression through #Microbiota-driven #Oncogenic mechanisms.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
May 28, 2026 at 12:16 PM
This study shows that #PsychologicalStress-induced #GutDysbiosis activates LRP5/β-catenin signaling, promoting #CancerStemness and tumor progression through #Microbiota-driven #Oncogenic mechanisms.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Fun Fact: Soo-mi wears a Wet Suit because of her Electric Organ mutation, she can control it sub concisely but she plays it safe for others safety. As for Zeya she can't swim cause of her LRP5 gene (Unbreakable Bones) so she gonna have to borrow Mei's floaties. (2/2)
July 22, 2026 at 1:27 AM
Fun Fact: Soo-mi wears a Wet Suit because of her Electric Organ mutation, she can control it sub concisely but she plays it safe for others safety. As for Zeya she can't swim cause of her LRP5 gene (Unbreakable Bones) so she gonna have to borrow Mei's floaties. (2/2)
LRP5-dependent transport of polyunsaturated fatty acids serves as an immune checkpoint for natural killer cells | Science Signaling www.science.org/doi/10.1126/... 🧪
LRP5-dependent transport of polyunsaturated fatty acids serves as an immune checkpoint for natural killer cells
Polyunsaturated fatty acids curb NK cell function and immunotherapy efficacy against colon cancer in mice.
www.science.org
August 19, 2026 at 7:29 AM
LRP5-dependent transport of polyunsaturated fatty acids serves as an immune checkpoint for natural killer cells | Science Signaling www.science.org/doi/10.1126/... 🧪
LRP5’in inhibisyonu, daha güvenli kan inceltme stratejileri için umut verici yaklaşımlar sundu.
LRP5’in inhibisyonu, mevcut ilaçlara kıyasla daha düşük kanama riskiyle birlikte trombosit aktivasyonunu ve trombozu azalttı.
LRP5’in inhibisyonu, mevcut ilaçlara kıyasla daha düşük kanama riskiyle birlikte trombosit aktivasyonunu ve trombozu azalttı.
June 18, 2026 at 10:23 AM
LRP5’in inhibisyonu, daha güvenli kan inceltme stratejileri için umut verici yaklaşımlar sundu.
LRP5’in inhibisyonu, mevcut ilaçlara kıyasla daha düşük kanama riskiyle birlikte trombosit aktivasyonunu ve trombozu azalttı.
LRP5’in inhibisyonu, mevcut ilaçlara kıyasla daha düşük kanama riskiyle birlikte trombosit aktivasyonunu ve trombozu azalttı.
This requires Ena/VASP proteins and is specifically promoted by Mena. Upon Wnt stimulation, Mena redistributes from focal adhesions to signalosomes, Wnt-receptor clusters. Mena directly binds Wnt-coreceptors LRP5/6 in a phosphorylation-dependent manner increasing Wnt signal transduction.
November 25, 2025 at 10:58 AM
This requires Ena/VASP proteins and is specifically promoted by Mena. Upon Wnt stimulation, Mena redistributes from focal adhesions to signalosomes, Wnt-receptor clusters. Mena directly binds Wnt-coreceptors LRP5/6 in a phosphorylation-dependent manner increasing Wnt signal transduction.
A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increasing PDGFB signaling https://www.biorxiv.org/content/10.64898/2026.03.13.711629v1
March 17, 2026 at 12:33 PM
A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increasing PDGFB signaling https://www.biorxiv.org/content/10.64898/2026.03.13.711629v1
The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in Drosophila https://www.biorxiv.org/content/10.1101/2025.09.22.677847v1
September 22, 2025 at 11:31 PM
The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in Drosophila https://www.biorxiv.org/content/10.1101/2025.09.22.677847v1
Cryo-EM reveals a 2:4:2 structure of Wnt3a/Fzd8/LRP6 complexes, showcasing Wnt3a-Wnt3a dimerization crucial for Wnt signaling via Fzd and LRP5/6 interaction. PMID:42202788, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00523-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00523-4
No description available
www.cell.com
July 15, 2026 at 9:00 AM
So that is why I prefer genetic engineering to mutate LRP5, BMP2, reinforce ACTN3, UCP1, PPARa, and edit PIEZO2 then our LGBTQ+ can just fly out of those Maga to the sky.
Also, we soon have vaccine or crispr to fully cure ppl from HIVs or STIs, cancer, disease, virvus infection too.
Also, we soon have vaccine or crispr to fully cure ppl from HIVs or STIs, cancer, disease, virvus infection too.
March 14, 2025 at 4:26 PM
So that is why I prefer genetic engineering to mutate LRP5, BMP2, reinforce ACTN3, UCP1, PPARa, and edit PIEZO2 then our LGBTQ+ can just fly out of those Maga to the sky.
Also, we soon have vaccine or crispr to fully cure ppl from HIVs or STIs, cancer, disease, virvus infection too.
Also, we soon have vaccine or crispr to fully cure ppl from HIVs or STIs, cancer, disease, virvus infection too.
The authors included RRIDs in their in Disease Models & Mechanisms paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #BetterScience #OpenScience
The class A repeats of Lrp5 are required for normal development of bone, retinal vasculature, and mammary gland in vivo
Read the full paper: The class A repeats of Lrp5 are required for normal development of bone, retinal vasculature, and mammary gland in vivo
doi.org
May 28, 2026 at 7:15 AM
The authors included RRIDs in their in Disease Models & Mechanisms paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #BetterScience #OpenScience