Researchers link microscopic protein structures and cellular interactions to individual differences in brain connectivity, offering new insights into brain function and variability.

Genomic organization and its comparative analysis throughout all major kingdoms of life are extensively studied across multiple scales, ranging from individual gene-level analyses to system-wide inves...

Abstract. The resources required to study gene function are limited, especially when considering the number of genes in the human genome and the complexity

The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split intein–mediated protein splicing, genetic code expansion,...

A study published in Science Advances reveals that the TRF2 protein plays a vital role beyond its traditional function of protecting chromosome ends. Researchers at the University of Pennsylvania found that TRF, which is essential for maintaining muscle stem cell identity, coordinates the regeneration process after injury. When TRF2 was removed from laboratory mice, their muscle stem cells lost functional characteristics, leading to fat and scar tissue accumulation in damaged areas. This discovery could advance treatments for muscular dystrophy and provide insights into cancer biology. The study also showed that TRF2 interacts with genomic regions containing G-quadruplexes, which are being explored as potential cancer targets. Additionally, mice lacking TRF2 in a Duchenne muscular dystrophy model experienced accelerated disease progression and shorter lifespans. These findings highlight the dual role of TRF2 in preserving muscle stem cell function while offering new avenues for regenerative medicine and understanding tissue-specific biological mechanisms.