Can NEIL #glycosylases protect #GenomeStability beyond base excision repair?
This review shows NEIL1–3 link BER to replication, transcription, mitochondria, immunity, and epigenetics, with dysregulation shaping #cancer and other diseases.
#GenesAndDiseases: doi.org/10.1016/j.ge...
This review shows NEIL1–3 link BER to replication, transcription, mitochondria, immunity, and epigenetics, with dysregulation shaping #cancer and other diseases.
#GenesAndDiseases: doi.org/10.1016/j.ge...
September 21, 2026 at 3:45 PM
Can NEIL #glycosylases protect #GenomeStability beyond base excision repair?
This review shows NEIL1–3 link BER to replication, transcription, mitochondria, immunity, and epigenetics, with dysregulation shaping #cancer and other diseases.
#GenesAndDiseases: doi.org/10.1016/j.ge...
This review shows NEIL1–3 link BER to replication, transcription, mitochondria, immunity, and epigenetics, with dysregulation shaping #cancer and other diseases.
#GenesAndDiseases: doi.org/10.1016/j.ge...
This reveals how RNA-binding proteins activate DNA-damage sensors, opening precise and reversible strategies to bypass tumor resistance.
📄 Source: www.cell.com/molecular-ce...
#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
📄 Source: www.cell.com/molecular-ce...
#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
September 10, 2026 at 10:00 AM
This reveals how RNA-binding proteins activate DNA-damage sensors, opening precise and reversible strategies to bypass tumor resistance.
📄 Source: www.cell.com/molecular-ce...
#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
📄 Source: www.cell.com/molecular-ce...
#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
Preclinical studies using mouse models showed that inhibiting the ATR pathway with elimusertib significantly decreases tumor growth and prolongs progression-free survival.
📄 Source: doi.org/10.1158/0008...
#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
📄 Source: doi.org/10.1158/0008...
#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
FET Fusion Oncoproteins Disrupt Physiologic DNA Repair and Create a Targetable Opportunity for ATR Inhibitor Therapy
FET fusion oncoproteins subvert genome maintenance by impairing ATM activity, bridging two key fields—oncogene biology and DNA repair—and proposing ATR inhibition as a targeted therapeutic approach…
doi.org
September 1, 2026 at 10:00 AM
Preclinical studies using mouse models showed that inhibiting the ATR pathway with elimusertib significantly decreases tumor growth and prolongs progression-free survival.
📄 Source: doi.org/10.1158/0008...
#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
📄 Source: doi.org/10.1158/0008...
#MolecularIntegrity #MolecularBiology #DNARepair #GenomeStability #SciComm
🧬Can a cancer-driving gene protect our genome?
In melanoma, MITF is an oncogene. But a new study shows that in non-melanocytic cancers, its depletion triggers genomic instability & apoptosis.
An amazing case of context-dependent protein duality!
#MolecularBiology #GeneRegulation #GenomeStability
In melanoma, MITF is an oncogene. But a new study shows that in non-melanocytic cancers, its depletion triggers genomic instability & apoptosis.
An amazing case of context-dependent protein duality!
#MolecularBiology #GeneRegulation #GenomeStability
FEBS Press
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2-mediated P53...
doi.org
August 27, 2026 at 10:00 AM
🧬Can a cancer-driving gene protect our genome?
In melanoma, MITF is an oncogene. But a new study shows that in non-melanocytic cancers, its depletion triggers genomic instability & apoptosis.
An amazing case of context-dependent protein duality!
#MolecularBiology #GeneRegulation #GenomeStability
In melanoma, MITF is an oncogene. But a new study shows that in non-melanocytic cancers, its depletion triggers genomic instability & apoptosis.
An amazing case of context-dependent protein duality!
#MolecularBiology #GeneRegulation #GenomeStability
Let’s spread the science! #DNARepair #GenomeStability #NuclearOrganization #Cancer #Aging #MolecularBiology #ScienceCollaboration
March 18, 2025 at 1:49 PM
Let’s spread the science! #DNARepair #GenomeStability #NuclearOrganization #Cancer #Aging #MolecularBiology #ScienceCollaboration
We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance.
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
PhD Studentship: Understanding How Centromere Replication Fails in Cancer Imperial College London & The Institute of Cancer Research (CRUK Convergence Science Centre) at Institute of Cancer Research o...
PhD Project - PhD Studentship: Understanding How Centromere Replication Fails in Cancer Imperial College London & The Institute of Cancer Research (CRUK Convergence Science Centre) at Institute of...
www.findaphd.com
December 18, 2025 at 3:46 PM
We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance.
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
👉 Don’t miss this opportunity to explore how chromatin remodelling and DNA repair mechanisms preserve genome stability.
#Chromatin #DNARepair #GenomeStability #MolecularBiology
@csiccyl.bsky.social
@usaloficial.bsky.social
#Chromatin #DNARepair #GenomeStability #MolecularBiology
@csiccyl.bsky.social
@usaloficial.bsky.social
May 12, 2026 at 12:24 PM
👉 Don’t miss this opportunity to explore how chromatin remodelling and DNA repair mechanisms preserve genome stability.
#Chromatin #DNARepair #GenomeStability #MolecularBiology
@csiccyl.bsky.social
@usaloficial.bsky.social
#Chromatin #DNARepair #GenomeStability #MolecularBiology
@csiccyl.bsky.social
@usaloficial.bsky.social
👉 Don’t miss this opportunity to discover how single-molecule techniques uncover the mechanics of protein machines in DNA metabolism 🔬🧬⚙️
#SingleMolecule #DNAMetabolism #MolecularMachines #GenomeStability
#SingleMolecule #DNAMetabolism #MolecularMachines #GenomeStability
April 14, 2026 at 9:10 AM
👉 Don’t miss this opportunity to discover how single-molecule techniques uncover the mechanics of protein machines in DNA metabolism 🔬🧬⚙️
#SingleMolecule #DNAMetabolism #MolecularMachines #GenomeStability
#SingleMolecule #DNAMetabolism #MolecularMachines #GenomeStability
👉 Don’t miss this opportunity to discover how chromosomes accurately pair and how crossovers are precisely regulated during meiosis.
#Meiosis #GeneticRecombination #GenomeStability #MolecularBiology
#Meiosis #GeneticRecombination #GenomeStability #MolecularBiology
April 7, 2026 at 7:26 AM
👉 Don’t miss this opportunity to discover how chromosomes accurately pair and how crossovers are precisely regulated during meiosis.
#Meiosis #GeneticRecombination #GenomeStability #MolecularBiology
#Meiosis #GeneticRecombination #GenomeStability #MolecularBiology
👉 Don’t miss this opportunity to explore the intricate regulatory mechanisms that safeguard genome stability and uncover new layers of translational control shaping enzyme function.
#GenomeStability #DNARepair #MolecularBiology #TranslationalControl
#GenomeStability #DNARepair #MolecularBiology #TranslationalControl
March 2, 2026 at 2:01 PM
👉 Don’t miss this opportunity to explore the intricate regulatory mechanisms that safeguard genome stability and uncover new layers of translational control shaping enzyme function.
#GenomeStability #DNARepair #MolecularBiology #TranslationalControl
#GenomeStability #DNARepair #MolecularBiology #TranslationalControl
Super excited for my first day as Assistant Prof at @cuanschutz.bsky.social in the Dept of Pharmacology! The lab is open, and now I can't wait to do exciting science! #FirstGen #newPI #STEM #AcademicLife #ExcitingScience #PhDLife #WomenInSTEM #MomInSTEM #GenomeStability #CellBiology #DNARepair
December 2, 2024 at 11:41 PM
Super excited for my first day as Assistant Prof at @cuanschutz.bsky.social in the Dept of Pharmacology! The lab is open, and now I can't wait to do exciting science! #FirstGen #newPI #STEM #AcademicLife #ExcitingScience #PhDLife #WomenInSTEM #MomInSTEM #GenomeStability #CellBiology #DNARepair
RESEARCH PAPER: Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR
By Yoon et al. and Satya Prakash
➡️ https://genesdev.cshlp.org/content/40/13-14/1059.abstract
UTMB Health
#DNAreplication #DNArepair #genomestability #translesionsynthesis
By Yoon et al. and Satya Prakash
➡️ https://genesdev.cshlp.org/content/40/13-14/1059.abstract
UTMB Health
#DNAreplication #DNArepair #genomestability #translesionsynthesis
July 9, 2026 at 6:00 PM
RESEARCH PAPER: Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR
By Yoon et al. and Satya Prakash
➡️ https://genesdev.cshlp.org/content/40/13-14/1059.abstract
UTMB Health
#DNAreplication #DNArepair #genomestability #translesionsynthesis
By Yoon et al. and Satya Prakash
➡️ https://genesdev.cshlp.org/content/40/13-14/1059.abstract
UTMB Health
#DNAreplication #DNArepair #genomestability #translesionsynthesis
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR
By Yoon et al. and Satya Prakash
➡️ https://ow.ly/l24j50Z5LM6
UTMB Health
#DNAreplication #translesionsynthesis #genomestability #DNArepair
RESEARCH PAPER: Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR
By Yoon et al. and Satya Prakash
➡️ https://ow.ly/l24j50Z5LM6
UTMB Health
#DNAreplication #translesionsynthesis #genomestability #DNArepair
June 2, 2026 at 3:00 PM
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR
By Yoon et al. and Satya Prakash
➡️ https://ow.ly/l24j50Z5LM6
UTMB Health
#DNAreplication #translesionsynthesis #genomestability #DNArepair
RESEARCH PAPER: Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR
By Yoon et al. and Satya Prakash
➡️ https://ow.ly/l24j50Z5LM6
UTMB Health
#DNAreplication #translesionsynthesis #genomestability #DNArepair
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration
By Tracy, Chen and ZZ Zhao Zhang
➡️ https://genesdev.cshlp.org/content/early/2026/01/22/gad.353011.125.abstract
#retrotransposon #Drosophila #genomestability
RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration
By Tracy, Chen and ZZ Zhao Zhang
➡️ https://genesdev.cshlp.org/content/early/2026/01/22/gad.353011.125.abstract
#retrotransposon #Drosophila #genomestability
February 23, 2026 at 7:00 PM
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration
By Tracy, Chen and ZZ Zhao Zhang
➡️ https://genesdev.cshlp.org/content/early/2026/01/22/gad.353011.125.abstract
#retrotransposon #Drosophila #genomestability
RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration
By Tracy, Chen and ZZ Zhao Zhang
➡️ https://genesdev.cshlp.org/content/early/2026/01/22/gad.353011.125.abstract
#retrotransposon #Drosophila #genomestability
Great to be back in Cambridge for this year's GSN. Some amazing talks and so great to reconnect with colleagues and to make new acquaintances.
#GSN #genomestability #chromatin #DNA
#GSN #genomestability #chromatin #DNA
January 18, 2026 at 9:27 AM
Great to be back in Cambridge for this year's GSN. Some amazing talks and so great to reconnect with colleagues and to make new acquaintances.
#GSN #genomestability #chromatin #DNA
#GSN #genomestability #chromatin #DNA
It was discovered that moss BRCA2 lacks the typical DNA-binding domain found in most organisms. Surprisingly, it can still bind DNA using a flexible region of the protein.
#GenomeStability
#GenomeStability
March 13, 2026 at 3:35 AM
It was discovered that moss BRCA2 lacks the typical DNA-binding domain found in most organisms. Surprisingly, it can still bind DNA using a flexible region of the protein.
#GenomeStability
#GenomeStability
A transcription balance required for genome stability 🧬⚖️
Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on @natsmb.nature.com
#CryoEM #transcription #genomestability
www.nature.com/articles/s41...
Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on @natsmb.nature.com
#CryoEM #transcription #genomestability
www.nature.com/articles/s41...
Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation - Nature Structural & Molecular Biology
Using cryo-electron microscopy and biochemistry, Zhang et al. reveal that the DNA helicase RECQL5 and the transcription-coupled DNA repair complex coordinate to regulate transcription elongation rates...
www.nature.com
July 7, 2025 at 2:00 PM
A transcription balance required for genome stability 🧬⚖️
Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on @natsmb.nature.com
#CryoEM #transcription #genomestability
www.nature.com/articles/s41...
Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on @natsmb.nature.com
#CryoEM #transcription #genomestability
www.nature.com/articles/s41...
A cell’s defense system can also become its vulnerability.
The perspective from Loretta Dorstyn & Sharad Kumar the “caspase-2 paradox” — how genome surveillance shapes liver polyploidy, homeostasis, and cancer risk: sciexplor.com/exo/articles...
#Polyploidy #GenomeStability #CancerResearch
The perspective from Loretta Dorstyn & Sharad Kumar the “caspase-2 paradox” — how genome surveillance shapes liver polyploidy, homeostasis, and cancer risk: sciexplor.com/exo/articles...
#Polyploidy #GenomeStability #CancerResearch
June 23, 2026 at 2:10 AM
A cell’s defense system can also become its vulnerability.
The perspective from Loretta Dorstyn & Sharad Kumar the “caspase-2 paradox” — how genome surveillance shapes liver polyploidy, homeostasis, and cancer risk: sciexplor.com/exo/articles...
#Polyploidy #GenomeStability #CancerResearch
The perspective from Loretta Dorstyn & Sharad Kumar the “caspase-2 paradox” — how genome surveillance shapes liver polyploidy, homeostasis, and cancer risk: sciexplor.com/exo/articles...
#Polyploidy #GenomeStability #CancerResearch
Replication stress derails placental development, threatening embryo survival. #placenta #genomestability
Study from the Schimenti lab @cornelluniversity.bsky.social
#Preprintpeerreview by @reviewcommons.org
Reviews & Author's response available here👇
doi.org/10.1101/2025...
Study from the Schimenti lab @cornelluniversity.bsky.social
#Preprintpeerreview by @reviewcommons.org
Reviews & Author's response available here👇
doi.org/10.1101/2025...
doi.org
April 23, 2026 at 8:02 PM
Replication stress derails placental development, threatening embryo survival. #placenta #genomestability
Study from the Schimenti lab @cornelluniversity.bsky.social
#Preprintpeerreview by @reviewcommons.org
Reviews & Author's response available here👇
doi.org/10.1101/2025...
Study from the Schimenti lab @cornelluniversity.bsky.social
#Preprintpeerreview by @reviewcommons.org
Reviews & Author's response available here👇
doi.org/10.1101/2025...
Cells delay division when DNA bridges persist—Srs2/PARI help prevent chromosome breakage. #genomestability #cellcycle
Study from Mendoza lab @longchrom.bsky.social @igbmc.bsky.social
#Preprintpeerreivew by @reviewcommons.org
Reviews & Author's response 👇 available here
doi.org/10.1101/2024...
Study from Mendoza lab @longchrom.bsky.social @igbmc.bsky.social
#Preprintpeerreivew by @reviewcommons.org
Reviews & Author's response 👇 available here
doi.org/10.1101/2024...
doi.org
April 23, 2026 at 7:50 PM
Cells delay division when DNA bridges persist—Srs2/PARI help prevent chromosome breakage. #genomestability #cellcycle
Study from Mendoza lab @longchrom.bsky.social @igbmc.bsky.social
#Preprintpeerreivew by @reviewcommons.org
Reviews & Author's response 👇 available here
doi.org/10.1101/2024...
Study from Mendoza lab @longchrom.bsky.social @igbmc.bsky.social
#Preprintpeerreivew by @reviewcommons.org
Reviews & Author's response 👇 available here
doi.org/10.1101/2024...
Stucki and colleague @show how MDC1 recruits E3 ligases to repair DNA breaks 🧬🔬 #GenomeStability #DNADamageRepair
bioRxiv doi.org/10.1101/2024.07.20.60439
bioRxiv doi.org/10.1101/2024.07.20.60439
doi.org
March 27, 2025 at 10:38 AM
Stucki and colleague @show how MDC1 recruits E3 ligases to repair DNA breaks 🧬🔬 #GenomeStability #DNADamageRepair
bioRxiv doi.org/10.1101/2024.07.20.60439
bioRxiv doi.org/10.1101/2024.07.20.60439
What if we could stop DNA repair errors before they happen — by moving the damage out of danger? #DNAdamage #CancerResearch #GenomeStability
How Protein Droplets Shield DNA From Catastrophic Errors
A newly discovered function of the Nup98 protein reveals how cells escort fragile DNA out of danger zones — offering clues for cancer therapy and anti-aging science.
geekoo.news
June 10, 2025 at 11:02 PM
What if we could stop DNA repair errors before they happen — by moving the damage out of danger? #DNAdamage #CancerResearch #GenomeStability
There's also a chance for YOU to share your science. 🔬
Registration closes 5 June 2026.
👉 Details + registration link: replifate.eu/event/meetin...
#DNAReplication #GenomeStability #Chromatin #MolecularBiology #MSCA #HorizonEurope #RepliFate
Registration closes 5 June 2026.
👉 Details + registration link: replifate.eu/event/meetin...
#DNAReplication #GenomeStability #Chromatin #MolecularBiology #MSCA #HorizonEurope #RepliFate
Events for May 2026
06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...
replifate.eu
May 28, 2026 at 5:29 PM
There's also a chance for YOU to share your science. 🔬
Registration closes 5 June 2026.
👉 Details + registration link: replifate.eu/event/meetin...
#DNAReplication #GenomeStability #Chromatin #MolecularBiology #MSCA #HorizonEurope #RepliFate
Registration closes 5 June 2026.
👉 Details + registration link: replifate.eu/event/meetin...
#DNAReplication #GenomeStability #Chromatin #MolecularBiology #MSCA #HorizonEurope #RepliFate