Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....
Identification of the mammalian VPS4A as a selective lipophagy receptor
www.tandfonline.com
January 5, 2025 at 9:13 PM
Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....
Spotlight: Yan Zhao previews work from Qiming Sun and colleagues (rupress.org/jcb/article/...), which shows how Rab #GTPases serve as cues for cargo receptor recruitment, mediating #mitophagy, #lipophagy, and #xenophagy. rupress.org/jcb/article/...
#autophagy
#autophagy
April 10, 2025 at 4:18 PM
Spotlight: Yan Zhao previews work from Qiming Sun and colleagues (rupress.org/jcb/article/...), which shows how Rab #GTPases serve as cues for cargo receptor recruitment, mediating #mitophagy, #lipophagy, and #xenophagy. rupress.org/jcb/article/...
#autophagy
#autophagy
Rab #GTPases are evolutionarily conserved signals mediating selective #autophagy, say Pengwei Zhao, Rui Tian, Dandan Song, Qi Zhu, Xianming Ding, Wei Zou, Qiming Sun and colleagues @ZJU_China: rupress.org/jcb/article/...
#Trafficking #Biochemistry #Mitophagy #Lipophagy #Xenophagy
#Trafficking #Biochemistry #Mitophagy #Lipophagy #Xenophagy
April 15, 2025 at 7:13 PM
Rab #GTPases are evolutionarily conserved signals mediating selective #autophagy, say Pengwei Zhao, Rui Tian, Dandan Song, Qi Zhu, Xianming Ding, Wei Zou, Qiming Sun and colleagues @ZJU_China: rupress.org/jcb/article/...
#Trafficking #Biochemistry #Mitophagy #Lipophagy #Xenophagy
#Trafficking #Biochemistry #Mitophagy #Lipophagy #Xenophagy
Tick– #virus interactions are poorly understood despite their impact on #disease #transmission. This study shows that #ticks hijack the JAK/STAT signaling pathway to drive LRP-mediated #lipophagy, supplying energy that enhances viral replication @plosbiology.org 🧪 plos.io/4tVRLWO
May 25, 2026 at 4:35 PM
Tick– #virus interactions are poorly understood despite their impact on #disease #transmission. This study shows that #ticks hijack the JAK/STAT signaling pathway to drive LRP-mediated #lipophagy, supplying energy that enhances viral replication @plosbiology.org 🧪 plos.io/4tVRLWO
This study from the labs of Wei Zou and Qiming Sun @ZJU_China uncovers Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation. rupress.org/jcb/article/...
#mitophagy #lipophagy #xenophagy
#mitophagy #lipophagy #xenophagy
April 8, 2025 at 5:11 PM
This study from the labs of Wei Zou and Qiming Sun @ZJU_China uncovers Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation. rupress.org/jcb/article/...
#mitophagy #lipophagy #xenophagy
#mitophagy #lipophagy #xenophagy
PISD acts as a switch between #lipophagy and fatty acid transfer to #mitochondria. From Hanbing Xue, Xingwen Hu, Zhenni Yang, Yan G. Zhao and colleagues: rupress.org/jcb/article/...
📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti...
#EMBOLipidCode
📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti...
#EMBOLipidCode
September 9, 2026 at 10:15 AM
PISD acts as a switch between #lipophagy and fatty acid transfer to #mitochondria. From Hanbing Xue, Xingwen Hu, Zhenni Yang, Yan G. Zhao and colleagues: rupress.org/jcb/article/...
📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti...
#EMBOLipidCode
📕 From our #Lipid and #Membrane collection: rupress.org/jcb/collecti...
#EMBOLipidCode
Characterization of Vlf1 as a regulator of lipophagy www.biorxiv.org/content/10.6...
Characterization of Vlf1 as a regulator of lipophagy
Lipid droplets (LDs) are unique organelles, surrounded by a phospholipid monolayer. They are present in most eukaryotic cells including the unicellular model organism S. cerevisiae . LDs store neutral...
www.biorxiv.org
August 13, 2026 at 4:38 PM
Characterization of Vlf1 as a regulator of lipophagy www.biorxiv.org/content/10.6...
Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic islets
https://www.biorxiv.org/content/10.1101/2024.11.17.624030v1
https://www.biorxiv.org/content/10.1101/2024.11.17.624030v1
November 28, 2024 at 1:23 PM
Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic islets
https://www.biorxiv.org/content/10.1101/2024.11.17.624030v1
https://www.biorxiv.org/content/10.1101/2024.11.17.624030v1
Tick– #virus interactions are poorly understood despite their impact on #disease #transmission. This study shows that #ticks hijack the JAK/STAT signaling pathway to drive LRP-mediated #lipophagy, supplying energy that enhances viral replication @plosbiology.org 🧪 plos.io/4tVRLWO
May 25, 2026 at 1:05 PM
Tick– #virus interactions are poorly understood despite their impact on #disease #transmission. This study shows that #ticks hijack the JAK/STAT signaling pathway to drive LRP-mediated #lipophagy, supplying energy that enhances viral replication @plosbiology.org 🧪 plos.io/4tVRLWO
#Medsky🧪 #IDsky #immunosky #publichealth
This study has identified tRF-His-GTG-1 (a transfer RNA derived fragment ) enriched in platelet derived extracellular vesicles (pEVs) as a critical driver of neutrophil lipophagy dysfunction & hyperinflammation in both acute & #long’COVID.
This study has identified tRF-His-GTG-1 (a transfer RNA derived fragment ) enriched in platelet derived extracellular vesicles (pEVs) as a critical driver of neutrophil lipophagy dysfunction & hyperinflammation in both acute & #long’COVID.
January 15, 2026 at 1:20 PM
#Medsky🧪 #IDsky #immunosky #publichealth
This study has identified tRF-His-GTG-1 (a transfer RNA derived fragment ) enriched in platelet derived extracellular vesicles (pEVs) as a critical driver of neutrophil lipophagy dysfunction & hyperinflammation in both acute & #long’COVID.
This study has identified tRF-His-GTG-1 (a transfer RNA derived fragment ) enriched in platelet derived extracellular vesicles (pEVs) as a critical driver of neutrophil lipophagy dysfunction & hyperinflammation in both acute & #long’COVID.
Rab GTPases as "eat me" signals for selective #autophagy. Yan Zhao discusses new work from Qiming Sun and colleagues (rupress.org/jcb/article/...), which shows how Rab GTPases serve as cues for cargo receptor recruitment, mediating #mitophagy, #lipophagy, and #xenophagy. rupress.org/jcb/article/...
April 17, 2025 at 2:19 PM
Rab GTPases as "eat me" signals for selective #autophagy. Yan Zhao discusses new work from Qiming Sun and colleagues (rupress.org/jcb/article/...), which shows how Rab GTPases serve as cues for cargo receptor recruitment, mediating #mitophagy, #lipophagy, and #xenophagy. rupress.org/jcb/article/...
New paper from the lab identifying the selective receptor for autophagy of lipid droplets:
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
VPS4A is the selective receptor for lipophagy in mice and humans
Das et al. show that VPS4A regulates lysosomal LD turnover independent of its canonical
endosomal function. Phosphorylated VPS4A tethers LDs to LC3, facilitating selective
lipophagy. VPS4A levels corr...
www.cell.com
November 14, 2024 at 2:17 AM
New paper from the lab identifying the selective receptor for autophagy of lipid droplets:
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
From Taiwan:
Extracellular Vesicle-Delivered tRF-His-GTG-1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID-19
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC
Extracellular Vesicle-Delivered tRF-His-GTG-1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID-19
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC
![Extracellular Vesicle-Delivered tRF-His-GTG-1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID-19 — Tsai-Ling Liao et al.
"Human neutrophils incubated with EVs from patients with moderate to severe COVID-19 or long COVID exhibited increased [lipid droplet] accumulation, accompanied by elevated ROS production and NET DNA release (p < 0.05)." "These effects were absent in neutrophils exposed to EVs from healthy controls."](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:43rudsv62fuwsmnk7oppgtdy/bafkreifzk7g3pvvow4xt5l2eyd5ncqxblk57zn2zbgujlza2t6a7x2w7iu)
January 23, 2026 at 3:07 AM
From Taiwan:
Extracellular Vesicle-Delivered tRF-His-GTG-1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID-19
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC
Extracellular Vesicle-Delivered tRF-His-GTG-1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID-19
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Screenshot from latest Science for ME weekly update
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC
Novel Lipophagy Inducers as Potential Therapeutics for Lipid Metabolism Disorders https://www.biorxiv.org/content/10.1101/2025.03.11.642628v1
March 13, 2025 at 7:30 AM
Novel Lipophagy Inducers as Potential Therapeutics for Lipid Metabolism Disorders https://www.biorxiv.org/content/10.1101/2025.03.11.642628v1
GPI lipid remodeling regulates lipophagy by forming lipid domains in response to glucose deprivation www.biorxiv.org/content/10.6...
www.biorxiv.org
April 16, 2026 at 6:52 PM
GPI lipid remodeling regulates lipophagy by forming lipid domains in response to glucose deprivation www.biorxiv.org/content/10.6...
#LncRNA #Autophagy #Atherosclerosis
ASO against CARMN, Smooth Muscle Cell-specific LncRNA, in Apoe-/-🐭
⏫Lesion burden
⏫BODIPY+ foam cell-like SMCs
⏬Lesion #Autophagy
Casein Kinase 1α, directly bound to CARMN⏩
AKT-ATG7-Lipophagy-Cholesterol efflux
#CellDeathDis 2025
www.nature.com/articles/s41...
ASO against CARMN, Smooth Muscle Cell-specific LncRNA, in Apoe-/-🐭
⏫Lesion burden
⏫BODIPY+ foam cell-like SMCs
⏬Lesion #Autophagy
Casein Kinase 1α, directly bound to CARMN⏩
AKT-ATG7-Lipophagy-Cholesterol efflux
#CellDeathDis 2025
www.nature.com/articles/s41...
December 6, 2025 at 8:14 PM
#LncRNA #Autophagy #Atherosclerosis
ASO against CARMN, Smooth Muscle Cell-specific LncRNA, in Apoe-/-🐭
⏫Lesion burden
⏫BODIPY+ foam cell-like SMCs
⏬Lesion #Autophagy
Casein Kinase 1α, directly bound to CARMN⏩
AKT-ATG7-Lipophagy-Cholesterol efflux
#CellDeathDis 2025
www.nature.com/articles/s41...
ASO against CARMN, Smooth Muscle Cell-specific LncRNA, in Apoe-/-🐭
⏫Lesion burden
⏫BODIPY+ foam cell-like SMCs
⏬Lesion #Autophagy
Casein Kinase 1α, directly bound to CARMN⏩
AKT-ATG7-Lipophagy-Cholesterol efflux
#CellDeathDis 2025
www.nature.com/articles/s41...
Regulation of macroautophagy and microautophagic lipophagy by phosphatidylserine synthase Cho1 and external ethanolamine https://www.biorxiv.org/content/10.1101/2025.08.08.669440v1
August 11, 2025 at 3:30 PM
Regulation of macroautophagy and microautophagic lipophagy by phosphatidylserine synthase Cho1 and external ethanolamine https://www.biorxiv.org/content/10.1101/2025.08.08.669440v1
Hanbing Xue, Xingwen Hu, Zhenni Yang, Yan G. Zhao et al. reveal that during nutrient scarcity, the lipid droplet–localized PISD isoform, PISD-LD, ensures survival by bridging #LipidDroplets to #mitochondria for β-oxidation while simultaneously inhibiting #lipophagy rupress.org/jcb/article/...
July 13, 2026 at 5:31 PM
Hanbing Xue, Xingwen Hu, Zhenni Yang, Yan G. Zhao et al. reveal that during nutrient scarcity, the lipid droplet–localized PISD isoform, PISD-LD, ensures survival by bridging #LipidDroplets to #mitochondria for β-oxidation while simultaneously inhibiting #lipophagy rupress.org/jcb/article/...
Tick– #virus interactions are poorly understood despite their impact on #disease #transmission. This study shows that #ticks hijack the JAK/STAT signaling pathway to drive LRP-mediated #lipophagy, supplying energy that enhances viral replication @plosbiology.org 🧪 plos.io/4tVRLWO
May 26, 2026 at 7:55 AM
Tick– #virus interactions are poorly understood despite their impact on #disease #transmission. This study shows that #ticks hijack the JAK/STAT signaling pathway to drive LRP-mediated #lipophagy, supplying energy that enhances viral replication @plosbiology.org 🧪 plos.io/4tVRLWO
Mitochondrial protein nmd regulates lipophagy and general autophagy during development
#Drosophila
#Drosophila
Mitochondrial protein nmd regulates lipophagy and general autophagy during development
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
June 26, 2025 at 5:23 PM
Mitochondrial protein nmd regulates lipophagy and general autophagy during development
#Drosophila
#Drosophila
PLIN2 regulates microlipophagy to prevent excess FA flux to mitochondria in beta cells
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic islets
Knockdown (KD) of lipid droplet (LD) protein perilipin 2 (PLIN2) in beta cells impairs glucose-stimulated insulin secretion (GSIS) and mitochondrial function. Here, we addressed a pathway responsible ...
www.biorxiv.org
November 20, 2024 at 12:36 PM
PLIN2 regulates microlipophagy to prevent excess FA flux to mitochondria in beta cells
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Why does #ColorectalCancer keep resisting #5Fluorouracil chemotherapy?
This study shows that arachidonic acid–driven lipophagy sustains resistant cells, suggesting a strategy to restore chemotherapy sensitivity. #DrugResistance
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
This study shows that arachidonic acid–driven lipophagy sustains resistant cells, suggesting a strategy to restore chemotherapy sensitivity. #DrugResistance
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
September 23, 2026 at 11:45 AM
Why does #ColorectalCancer keep resisting #5Fluorouracil chemotherapy?
This study shows that arachidonic acid–driven lipophagy sustains resistant cells, suggesting a strategy to restore chemotherapy sensitivity. #DrugResistance
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
This study shows that arachidonic acid–driven lipophagy sustains resistant cells, suggesting a strategy to restore chemotherapy sensitivity. #DrugResistance
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
Novel Lipophagy Inducers as Potential Therapeutics for Lipid Metabolism Disorders https://www.biorxiv.org/content/10.1101/2025.03.11.642628v1
March 13, 2025 at 7:30 AM
Novel Lipophagy Inducers as Potential Therapeutics for Lipid Metabolism Disorders https://www.biorxiv.org/content/10.1101/2025.03.11.642628v1
Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function https://www.biorxiv.org/content/10.1101/2024.11.12.623285v1
Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function https://www.biorxiv.org/content/10.1101/2024.11.12.623285v1
Lipophagy is a form of selective autophagy that targets the lipid droplets for lysosomal decay and h
www.biorxiv.org
November 13, 2024 at 9:30 AM
Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function https://www.biorxiv.org/content/10.1101/2024.11.12.623285v1