Researchers have developed a molecule that boosts cells’ ability to repair oxidative #DNADamage. In human liver cells and mice, it reduced liver injury caused by paracetamol toxicity and improved survival. Published in Advanced Science. #LiverResearch 🧪
news.ki.se/new-molecule...
news.ki.se/new-molecule...
September 28, 2026 at 12:30 PM
Researchers have developed a molecule that boosts cells’ ability to repair oxidative #DNADamage. In human liver cells and mice, it reduced liver injury caused by paracetamol toxicity and improved survival. Published in Advanced Science. #LiverResearch 🧪
news.ki.se/new-molecule...
news.ki.se/new-molecule...
🔆 #PaperSpotlight:
A new #Review was published on August 31, titled “The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.”
🔗 https://bit.ly/4he09wj
#Aging #Quote #DNADamage #Senescence
A new #Review was published on August 31, titled “The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.”
🔗 https://bit.ly/4he09wj
#Aging #Quote #DNADamage #Senescence
September 21, 2026 at 10:00 PM
🔆 #PaperSpotlight:
A new #Review was published on August 31, titled “The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.”
🔗 https://bit.ly/4he09wj
#Aging #Quote #DNADamage #Senescence
A new #Review was published on August 31, titled “The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.”
🔗 https://bit.ly/4he09wj
#Aging #Quote #DNADamage #Senescence
🎥 #AgingShort:
Abstract #Video about the #Review, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.”
🔗 https://bit.ly/4he09wj
#Aging #OA #DNADamage #Senescence #Publishing
Abstract #Video about the #Review, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.”
🔗 https://bit.ly/4he09wj
#Aging #OA #DNADamage #Senescence #Publishing
September 21, 2026 at 6:00 PM
🎥 #AgingShort:
Abstract #Video about the #Review, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.”
🔗 https://bit.ly/4he09wj
#Aging #OA #DNADamage #Senescence #Publishing
Abstract #Video about the #Review, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.”
🔗 https://bit.ly/4he09wj
#Aging #OA #DNADamage #Senescence #Publishing
🔆 #PaperSpotlight:
"The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework"
#PressRelease ⬇️
https://bit.ly/4ycmdPi
#Aging #DNADamage #Senescence #OA #PeerReviewed #Press #DNA #Publishing
"The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework"
#PressRelease ⬇️
https://bit.ly/4ycmdPi
#Aging #DNADamage #Senescence #OA #PeerReviewed #Press #DNA #Publishing
The “Guardian Paradox” Links Chronic DNA Damage Response to Aging - Aging Journal
A new review was published in Volume 18 of Aging on August 31, 2026, titled “The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative re...
aging-us.net
September 21, 2026 at 5:20 PM
🔆 #PaperSpotlight:
"The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework"
#PressRelease ⬇️
https://bit.ly/4ycmdPi
#Aging #DNADamage #Senescence #OA #PeerReviewed #Press #DNA #Publishing
"The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework"
#PressRelease ⬇️
https://bit.ly/4ycmdPi
#Aging #DNADamage #Senescence #OA #PeerReviewed #Press #DNA #Publishing
✨NAR Molecular Medicine✨
⚠️ What happens when #DNArepair can no longer keep up? A study shows that increasing exposure to #NDMA can saturate #MGMT, triggering a burst of #mutations. A striking example of how dose shapes #DNAdamage and #cancerrisk. doi.org/10.1093/narm... @mitpress.bsky.social
⚠️ What happens when #DNArepair can no longer keep up? A study shows that increasing exposure to #NDMA can saturate #MGMT, triggering a burst of #mutations. A striking example of how dose shapes #DNAdamage and #cancerrisk. doi.org/10.1093/narm... @mitpress.bsky.social
September 16, 2026 at 4:43 AM
✨NAR Molecular Medicine✨
⚠️ What happens when #DNArepair can no longer keep up? A study shows that increasing exposure to #NDMA can saturate #MGMT, triggering a burst of #mutations. A striking example of how dose shapes #DNAdamage and #cancerrisk. doi.org/10.1093/narm... @mitpress.bsky.social
⚠️ What happens when #DNArepair can no longer keep up? A study shows that increasing exposure to #NDMA can saturate #MGMT, triggering a burst of #mutations. A striking example of how dose shapes #DNAdamage and #cancerrisk. doi.org/10.1093/narm... @mitpress.bsky.social
“HOMEODOMAIN GLABROUS 4 promotes DNA damage-induced stem cell death in Arabidopsis thaliana roots.” Wada et al. #Arabidopsisthaliana #CellDeath #DNADamage link.springer.com/article/10.1...
HOMEODOMAIN GLABROUS 4 promotes DNA damage-induced stem cell death in Arabidopsis thaliana roots - Journal of Plant Research
Maintenance of genomic integrity is essential for sustained cell proliferation in plant meristems. In Arabidopsis thaliana, the DNA damage response is controlled by the transcription factor SUPPRESSOR...
link.springer.com
August 24, 2026 at 2:17 AM
“HOMEODOMAIN GLABROUS 4 promotes DNA damage-induced stem cell death in Arabidopsis thaliana roots.” Wada et al. #Arabidopsisthaliana #CellDeath #DNADamage link.springer.com/article/10.1...
#CancerRisk mutations can be inherited, but where did they originate?
This study traces #DNAdamage repair gene variants across 40,000 years of human evolution, revealing how they emerged and spread among modern populations.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This study traces #DNAdamage repair gene variants across 40,000 years of human evolution, revealing how they emerged and spread among modern populations.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
August 22, 2026 at 4:30 PM
#CancerRisk mutations can be inherited, but where did they originate?
This study traces #DNAdamage repair gene variants across 40,000 years of human evolution, revealing how they emerged and spread among modern populations.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
This study traces #DNAdamage repair gene variants across 40,000 years of human evolution, revealing how they emerged and spread among modern populations.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
Follow @biohackingpathway for more
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
August 14, 2026 at 6:10 AM
Follow @biohackingpathway for more
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
PARP1 hyperactivity stalls translation and triggers #stressgranule formation following DNA damage. New study from Maria Tereshchenko, Rebecca Earnshaw
Hyun O. Lee @utoronto.ca:
rupress.org/jcb/article/...
#Physiology #CellSignaling #Biochemistry #DNAbiology #DNAdamage
Hyun O. Lee @utoronto.ca:
rupress.org/jcb/article/...
#Physiology #CellSignaling #Biochemistry #DNAbiology #DNAdamage
August 5, 2026 at 1:45 PM
PARP1 hyperactivity stalls translation and triggers #stressgranule formation following DNA damage. New study from Maria Tereshchenko, Rebecca Earnshaw
Hyun O. Lee @utoronto.ca:
rupress.org/jcb/article/...
#Physiology #CellSignaling #Biochemistry #DNAbiology #DNAdamage
Hyun O. Lee @utoronto.ca:
rupress.org/jcb/article/...
#Physiology #CellSignaling #Biochemistry #DNAbiology #DNAdamage
Tereshchenko, Earnshaw, Lee et al. @utoronto.ca show that #DNAdamage activates cytoplasmic stress responses that promote cell survival. rupress.org/jcb/article/...
#Physiology #CellSignaling #Biochemistry #DNAbiology
#Physiology #CellSignaling #Biochemistry #DNAbiology
July 29, 2026 at 4:00 PM
Tereshchenko, Earnshaw, Lee et al. @utoronto.ca show that #DNAdamage activates cytoplasmic stress responses that promote cell survival. rupress.org/jcb/article/...
#Physiology #CellSignaling #Biochemistry #DNAbiology
#Physiology #CellSignaling #Biochemistry #DNAbiology
🩰The Dance of Genetic Healing
Repair enzymes gently sculpt the DNA to heal wounds hidden deep within the cell’s tight embrace.
#MolecularBiology, #DNADamage, #DNARepair
www.sciencedirect.com/science/arti...
Repair enzymes gently sculpt the DNA to heal wounds hidden deep within the cell’s tight embrace.
#MolecularBiology, #DNADamage, #DNARepair
www.sciencedirect.com/science/arti...
Base excision repair in chromatin: A tug-of-war for DNA damage
Base excision repair (BER) is a genome surveillance pathway responsible for repairing DNA base lesions distributed throughout the chromatinized eukary…
www.sciencedirect.com
July 13, 2026 at 6:20 PM
🩰The Dance of Genetic Healing
Repair enzymes gently sculpt the DNA to heal wounds hidden deep within the cell’s tight embrace.
#MolecularBiology, #DNADamage, #DNARepair
www.sciencedirect.com/science/arti...
Repair enzymes gently sculpt the DNA to heal wounds hidden deep within the cell’s tight embrace.
#MolecularBiology, #DNADamage, #DNARepair
www.sciencedirect.com/science/arti...
Follow @biohackingpathway for more
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
July 8, 2026 at 11:07 PM
Follow @biohackingpathway for more
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
#Snail1 shapes cellular fate!
#Proteomic analysis of SNAI1-overexpressed renal tubular cells reveals altered stress responses, #RibosomeBiogenesis, senescence, #DNAdamage and focal adhesion remodeling, expanding #Snail1’s role in #KidneyFibrosis.
#OpenAccess: doi.org/10.1016/j.ge...
#Proteomic analysis of SNAI1-overexpressed renal tubular cells reveals altered stress responses, #RibosomeBiogenesis, senescence, #DNAdamage and focal adhesion remodeling, expanding #Snail1’s role in #KidneyFibrosis.
#OpenAccess: doi.org/10.1016/j.ge...
July 2, 2026 at 9:27 AM
#Snail1 shapes cellular fate!
#Proteomic analysis of SNAI1-overexpressed renal tubular cells reveals altered stress responses, #RibosomeBiogenesis, senescence, #DNAdamage and focal adhesion remodeling, expanding #Snail1’s role in #KidneyFibrosis.
#OpenAccess: doi.org/10.1016/j.ge...
#Proteomic analysis of SNAI1-overexpressed renal tubular cells reveals altered stress responses, #RibosomeBiogenesis, senescence, #DNAdamage and focal adhesion remodeling, expanding #Snail1’s role in #KidneyFibrosis.
#OpenAccess: doi.org/10.1016/j.ge...
Follow @biohackingpathway for more
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
June 2, 2026 at 4:27 PM
Follow @biohackingpathway for more
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
This study reveals that the protein KIN17 drives #EsophagealCancer progression by resolving R-loop-induced #DNAdamage, which suppresses a noncanonical STING pathway and helps the tumor evade innate immune responses.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
May 29, 2026 at 4:45 PM
This study reveals that the protein KIN17 drives #EsophagealCancer progression by resolving R-loop-induced #DNAdamage, which suppresses a noncanonical STING pathway and helps the tumor evade innate immune responses.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
1/2
🧬 For #DNArepair studies, chemically-induced damage is often too blunt.
🎯 Local laser-induced #DNAdamage changes the experimental game. Instead of damaging the whole sample, one can target a selected nuclear region and follow the response over time with #LiveImaging.
#Microscopy #Bioimaging
🧬 For #DNArepair studies, chemically-induced damage is often too blunt.
🎯 Local laser-induced #DNAdamage changes the experimental game. Instead of damaging the whole sample, one can target a selected nuclear region and follow the response over time with #LiveImaging.
#Microscopy #Bioimaging
May 28, 2026 at 11:38 AM
1/2
🧬 For #DNArepair studies, chemically-induced damage is often too blunt.
🎯 Local laser-induced #DNAdamage changes the experimental game. Instead of damaging the whole sample, one can target a selected nuclear region and follow the response over time with #LiveImaging.
#Microscopy #Bioimaging
🧬 For #DNArepair studies, chemically-induced damage is often too blunt.
🎯 Local laser-induced #DNAdamage changes the experimental game. Instead of damaging the whole sample, one can target a selected nuclear region and follow the response over time with #LiveImaging.
#Microscopy #Bioimaging
📢We are pleased to welcome Tereza Kratochvílová to our team. She will be Eva's @evadt.bsky.social first Ph.D. student, working primarily on the role of SUMO signaling in DNA damage sites. 🧬
We hope Tereza enjoys her time here and does well.
#PhD #SUMO #DNAdamage #Arabidopsis
We hope Tereza enjoys her time here and does well.
#PhD #SUMO #DNAdamage #Arabidopsis
May 27, 2026 at 6:28 AM
📢We are pleased to welcome Tereza Kratochvílová to our team. She will be Eva's @evadt.bsky.social first Ph.D. student, working primarily on the role of SUMO signaling in DNA damage sites. 🧬
We hope Tereza enjoys her time here and does well.
#PhD #SUMO #DNAdamage #Arabidopsis
We hope Tereza enjoys her time here and does well.
#PhD #SUMO #DNAdamage #Arabidopsis
Overproduction of the #DNARepair protein #exonuclease1 (#EXO1) in certain #cancers causes #DNADamage that mimics #BRCAmutations, potentially making these cancers responsive to the same #TargetedTreatments.
EXO1: DNA repair protein gene gone rogue may unlock new cancer treatments – BioNews Central
Overproduction of the DNA repair protein EXO1 in certain cancers causes DNA damage that mimics BRCA mutations, potentially making these cancers responsive to the same targeted treatments. ...
sbee.link
May 22, 2026 at 6:49 PM
Overproduction of the #DNARepair protein #exonuclease1 (#EXO1) in certain #cancers causes #DNADamage that mimics #BRCAmutations, potentially making these cancers responsive to the same #TargetedTreatments.
Comentario en JARG sobre los efectos y por qué vigilar el daño al ADN en reproducción asistida:
buff.ly/dWxRJLC
#bianorbiotech #ART #DNADamage #SDF #IVF
buff.ly/dWxRJLC
#bianorbiotech #ART #DNADamage #SDF #IVF
DNA damage control in IVF: precariously positioned between physiology and disease - Journal of Assisted Reproduction and Genetics
Journal of Assisted Reproduction and Genetics -
buff.ly
May 19, 2026 at 6:04 AM
Comentario en JARG sobre los efectos y por qué vigilar el daño al ADN en reproducción asistida:
buff.ly/dWxRJLC
#bianorbiotech #ART #DNADamage #SDF #IVF
buff.ly/dWxRJLC
#bianorbiotech #ART #DNADamage #SDF #IVF
Learn about the #DNAdamage response in #CellPhysiology and diseases in the eponymous EMBO Workshop in #Sounio, #Greece, 12–16 October 2026.
Deadline: 17 May 2026
https://meetings.embo.org/event/26-dna-damage
#EMBODNADamageResponse #genesky #LifeSciences #research #meeting #EMBOevents 🧪
Deadline: 17 May 2026
https://meetings.embo.org/event/26-dna-damage
#EMBODNADamageResponse #genesky #LifeSciences #research #meeting #EMBOevents 🧪
May 4, 2026 at 3:10 PM
Learn about the #DNAdamage response in #CellPhysiology and diseases in the eponymous EMBO Workshop in #Sounio, #Greece, 12–16 October 2026.
Deadline: 17 May 2026
https://meetings.embo.org/event/26-dna-damage
#EMBODNADamageResponse #genesky #LifeSciences #research #meeting #EMBOevents 🧪
Deadline: 17 May 2026
https://meetings.embo.org/event/26-dna-damage
#EMBODNADamageResponse #genesky #LifeSciences #research #meeting #EMBOevents 🧪
We are excited to share our latest research now published in Cell Reports. Together with Hyun Lee and Masato Kanemaki lab, we investigate the mechanism underlying the exclusion of FUS and EWSR1—and show that this process is driven by RNA pol II.
#dnarepair #fus #dnadamage #DDR #transcription
#dnarepair #fus #dnadamage #DDR #transcription
RNA polymerase II drives FUS and EWSR1 exclusion from damaged chromatin
RNA polymerase II drives FUS and EWSR1 exclusion from damaged chromatin
Using advanced live-cell imaging and targeted perturbation approaches, Varhoshkova et al. identify an RNA polymerase II-dependent mechanism that drives the exclusion of FUS and EWSR1 from complex DNA lesions and plays an important role in coordinating the DNA damage response.
dlvr.it
April 30, 2026 at 2:09 PM
We are excited to share our latest research now published in Cell Reports. Together with Hyun Lee and Masato Kanemaki lab, we investigate the mechanism underlying the exclusion of FUS and EWSR1—and show that this process is driven by RNA pol II.
#dnarepair #fus #dnadamage #DDR #transcription
#dnarepair #fus #dnadamage #DDR #transcription
Follow @biohackingpathway for more
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
April 27, 2026 at 8:07 AM
Follow @biohackingpathway for more
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging
New research shows that dialing down an overactive immune sensor can restore tissue health in severe #GeneticDisorders, reshaping how scientists think about #aging and #DNAdamage.
#ImmuneSystem #GenomicInstability
#ImmuneSystem #GenomicInstability
A new view of aging: How the immune system rewrites rapid aging – BioNews Central
New research shows that dialing down an overactive immune sensor can restore tissue health in severe genetic disorders, reshaping how scientists think about aging and DNA damage. ...
sbee.link
April 19, 2026 at 4:47 PM
New research shows that dialing down an overactive immune sensor can restore tissue health in severe #GeneticDisorders, reshaping how scientists think about #aging and #DNAdamage.
#ImmuneSystem #GenomicInstability
#ImmuneSystem #GenomicInstability
Irinotecan reverses #Anthracycline resistance by targeting AARS1-mediated BLM lactylation and homologous recombination repair, enhancing #DNAdamage sensitivity and improving therapeutic response in resistant #Cancers.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
April 19, 2026 at 2:50 PM
Irinotecan reverses #Anthracycline resistance by targeting AARS1-mediated BLM lactylation and homologous recombination repair, enhancing #DNAdamage sensitivity and improving therapeutic response in resistant #Cancers.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...