Staged cryo-ET points to modular assembly: inner-junction components are present early, while outer dynein arm occupancy increases as gametogenesis proceeds. #teamtomo #Plasmodium
October 5, 2026 at 2:58 AM
Staged cryo-ET points to modular assembly: inner-junction components are present early, while outer dynein arm occupancy increases as gametogenesis proceeds. #teamtomo #Plasmodium
📖 Open access via @cellpress.bsky.social: doi.org/10.1016/j.ce...
Big thanks to @embl.org for making this work possible.
#cryoET #StructuralBiology #Microbiology #AlphaFold #EMBL #TeamTomo
🧵(6/7)
Big thanks to @embl.org for making this work possible.
#cryoET #StructuralBiology #Microbiology #AlphaFold #EMBL #TeamTomo
🧵(6/7)
Redirecting
doi.org
September 25, 2026 at 3:20 PM
📖 Open access via @cellpress.bsky.social: doi.org/10.1016/j.ce...
Big thanks to @embl.org for making this work possible.
#cryoET #StructuralBiology #Microbiology #AlphaFold #EMBL #TeamTomo
🧵(6/7)
Big thanks to @embl.org for making this work possible.
#cryoET #StructuralBiology #Microbiology #AlphaFold #EMBL #TeamTomo
🧵(6/7)
MemBrain v2: streamlined analysis of membranes in cryo-ET with tools for membrane segmentation, protein localization and spatial analysis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography - Nature Methods
MemBrain v2 enables streamlined analysis of membranes in cryo-electron tomography by providing user-friendly tools for membrane segmentation, membrane protein localization and spatial analysis, suppor...
www.nature.com
September 24, 2026 at 12:15 PM
thrilled to share that my main phd project is finally out in @natcomms.nature.com
we present high-resolution structures of RyR1 in native membranes across multiple functional states by both cryo-ET/StA #TeamTomo and SPA!
paper: www.nature.com/articles/s41...
and a thread below⬇️⬇️⬇️
we present high-resolution structures of RyR1 in native membranes across multiple functional states by both cryo-ET/StA #TeamTomo and SPA!
paper: www.nature.com/articles/s41...
and a thread below⬇️⬇️⬇️
September 24, 2026 at 11:53 AM
thrilled to share that my main phd project is finally out in @natcomms.nature.com
we present high-resolution structures of RyR1 in native membranes across multiple functional states by both cryo-ET/StA #TeamTomo and SPA!
paper: www.nature.com/articles/s41...
and a thread below⬇️⬇️⬇️
we present high-resolution structures of RyR1 in native membranes across multiple functional states by both cryo-ET/StA #TeamTomo and SPA!
paper: www.nature.com/articles/s41...
and a thread below⬇️⬇️⬇️
... For the sponsoring the talk and poster prizes, that went to @fannyleblanc.bsky.social and Aurélien Gregor 🎊.
And huge thanks to @sofie-dot-rec.bsky.social, @phaips.vd.st and Imre Gonda for teaching the workshop on sample prep, data collection and processing on the 2nd day.
#cryoET #TeamTOMO
And huge thanks to @sofie-dot-rec.bsky.social, @phaips.vd.st and Imre Gonda for teaching the workshop on sample prep, data collection and processing on the 2nd day.
#cryoET #TeamTOMO
September 22, 2026 at 7:05 PM
... For the sponsoring the talk and poster prizes, that went to @fannyleblanc.bsky.social and Aurélien Gregor 🎊.
And huge thanks to @sofie-dot-rec.bsky.social, @phaips.vd.st and Imre Gonda for teaching the workshop on sample prep, data collection and processing on the 2nd day.
#cryoET #TeamTOMO
And huge thanks to @sofie-dot-rec.bsky.social, @phaips.vd.st and Imre Gonda for teaching the workshop on sample prep, data collection and processing on the 2nd day.
#cryoET #TeamTOMO
🧵 8/8: For more details, please check out our preprint:
www.biorxiv.org/content/10.6...
#chromatin #TeamTomo
www.biorxiv.org/content/10.6...
#chromatin #TeamTomo
Chromatin structure of the inactive X chromosome revealed by in situ cryo-electron tomography
The intricate organisation of chromatin in eukaryotic cells plays a central role in regulating gene transcription and other DNA-templated processes. Prior studies using light microscopy, biochemistry,...
www.biorxiv.org
September 14, 2026 at 8:39 AM
🧵 8/8: For more details, please check out our preprint:
www.biorxiv.org/content/10.6...
#chromatin #TeamTomo
www.biorxiv.org/content/10.6...
#chromatin #TeamTomo
Fist lab retreat finally happened 🌴+🦠
We came for the science. We stayed for the lake, the secrets, and between Cadenabbia and Bellagio, we took the time to deeply talk about every project in a beautiful scenery — and how we want to do it together.
Good people. Good science. Good vibes.☀️❄️🔬 #TeamTomo
We came for the science. We stayed for the lake, the secrets, and between Cadenabbia and Bellagio, we took the time to deeply talk about every project in a beautiful scenery — and how we want to do it together.
Good people. Good science. Good vibes.☀️❄️🔬 #TeamTomo
September 10, 2026 at 7:14 AM
Fist lab retreat finally happened 🌴+🦠
We came for the science. We stayed for the lake, the secrets, and between Cadenabbia and Bellagio, we took the time to deeply talk about every project in a beautiful scenery — and how we want to do it together.
Good people. Good science. Good vibes.☀️❄️🔬 #TeamTomo
We came for the science. We stayed for the lake, the secrets, and between Cadenabbia and Bellagio, we took the time to deeply talk about every project in a beautiful scenery — and how we want to do it together.
Good people. Good science. Good vibes.☀️❄️🔬 #TeamTomo
I am looking for a lab manager for my group that I will be starting at the @fmiscience.bsky.social in February! We will use in situ structural biology to investigate dynamic ciliary processes. More info here —> bsky.app/profile/comp... #cilia #teamtomo #proteomics #protistsky
📢 We’re hiring!
Join Caitlyn McCafferty’s (@computingcaitie.bsky.social) new group as Lab Manager and help shape lab operations, develop protocols and support research on the structure and dynamics of motile cilia. Apply by October 9: www.fmi.ch/education-ca...
Join Caitlyn McCafferty’s (@computingcaitie.bsky.social) new group as Lab Manager and help shape lab operations, develop protocols and support research on the structure and dynamics of motile cilia. Apply by October 9: www.fmi.ch/education-ca...
September 9, 2026 at 9:33 AM
I am looking for a lab manager for my group that I will be starting at the @fmiscience.bsky.social in February! We will use in situ structural biology to investigate dynamic ciliary processes. More info here —> bsky.app/profile/comp... #cilia #teamtomo #proteomics #protistsky
MemBrain v2 is on @natmethods.nature.com now? I never had a @biorxivpreprint.bsky.social with 164 citations before😅 ...Which is also to say: Thank you to the amazing #TeamTomo community, many of whom not only beta tested, but also contributed diverse training data. This one belongs to all of us! 🤗🔬🧪
September 8, 2026 at 11:10 AM
MemBrain v2 is on @natmethods.nature.com now? I never had a @biorxivpreprint.bsky.social with 164 citations before😅 ...Which is also to say: Thank you to the amazing #TeamTomo community, many of whom not only beta tested, but also contributed diverse training data. This one belongs to all of us! 🤗🔬🧪
Exciting news! Our @erc.europa.eu StG project ARCHAEAOLOGY got funded 🎉
We’ll combine cryoET/EM, ExM & spatial omics to explore the subcellular organization of Asgard archaea.
Job ads coming soon! 🦠 ❄️ 🔬
#TeamTomo #ArchaeaSky #MicroSky
We’ll combine cryoET/EM, ExM & spatial omics to explore the subcellular organization of Asgard archaea.
Job ads coming soon! 🦠 ❄️ 🔬
#TeamTomo #ArchaeaSky #MicroSky
Congratulations to @florianwollweber.bsky.social, the recently appointed Group Leader at EMBL Grenoble, who received an ERC Starting Grant worth approximately €2 million to investigate the origins of eukaryotic cell complexity.
bit.ly/4gNwEBk
bit.ly/4gNwEBk
September 5, 2026 at 12:57 PM
Exciting news! Our @erc.europa.eu StG project ARCHAEAOLOGY got funded 🎉
We’ll combine cryoET/EM, ExM & spatial omics to explore the subcellular organization of Asgard archaea.
Job ads coming soon! 🦠 ❄️ 🔬
#TeamTomo #ArchaeaSky #MicroSky
We’ll combine cryoET/EM, ExM & spatial omics to explore the subcellular organization of Asgard archaea.
Job ads coming soon! 🦠 ❄️ 🔬
#TeamTomo #ArchaeaSky #MicroSky
@ccpem.bsky.social
#cryoEM #cryoET #teamTOMO #structure #strucbio
I'd call this version 0.0.0. it's highly functional. Coded by parallel Claude agents and tested by running #Relion tutorials. This WebUI wraps #IsoNet2 into a Relion interface, internalizes picking jobs and ships securely in browser
#cryoEM #cryoET #teamTOMO #structure #strucbio
I'd call this version 0.0.0. it's highly functional. Coded by parallel Claude agents and tested by running #Relion tutorials. This WebUI wraps #IsoNet2 into a Relion interface, internalizes picking jobs and ships securely in browser
GitHub - schiracha/RELION-US: Relion Webbased GUI that is user built
Relion Webbased GUI that is user built. Contribute to schiracha/RELION-US development by creating an account on GitHub.
github.com
September 5, 2026 at 12:23 AM
@ccpem.bsky.social
#cryoEM #cryoET #teamTOMO #structure #strucbio
I'd call this version 0.0.0. it's highly functional. Coded by parallel Claude agents and tested by running #Relion tutorials. This WebUI wraps #IsoNet2 into a Relion interface, internalizes picking jobs and ships securely in browser
#cryoEM #cryoET #teamTOMO #structure #strucbio
I'd call this version 0.0.0. it's highly functional. Coded by parallel Claude agents and tested by running #Relion tutorials. This WebUI wraps #IsoNet2 into a Relion interface, internalizes picking jobs and ships securely in browser
Every electron counts⚛️! Researchers have determined the structure of the protein rubredoxin at an unprecedented 0.43 Ångström resolution. The method could now allow routine quantum crystallography of biological macromolecules.
👇More about this major advancement: www.mpinat.mpg.de/5314392/rn_2...
👇More about this major advancement: www.mpinat.mpg.de/5314392/rn_2...
September 2, 2026 at 2:28 PM
Austin Powers: Goldmember - I Love Gold!
ALT: Austin Powers: Goldmember - I Love Gold!
static.klipy.com
September 2, 2026 at 12:37 AM
#Claude ran through the SPA #cryoEM tutorial for #Relion.
Some bugs, fixes, improvements.
Relion-US custom web UI for Relion w/ some add-ins
job010 3DRefine reporting 7.0A resolution.
Realtime job tracking w/ some charts.
Picking tools, Import Tools, more to come
#Branch, #Fork, #JoinUS #teamtomo
Some bugs, fixes, improvements.
Relion-US custom web UI for Relion w/ some add-ins
job010 3DRefine reporting 7.0A resolution.
Realtime job tracking w/ some charts.
Picking tools, Import Tools, more to come
#Branch, #Fork, #JoinUS #teamtomo
September 1, 2026 at 5:11 PM
#cryoEM #cryoET #teamTOMO #Relion ❄️🔬
#IMOD /DeepETPicker style picker. Custom jobs for #SingleParticle and #Tomography. Not fully tested yet, little buggy on particle import. Have not stress tested the file caching so may need to split those star files, but opened 10 tomograms in test
#IMOD /DeepETPicker style picker. Custom jobs for #SingleParticle and #Tomography. Not fully tested yet, little buggy on particle import. Have not stress tested the file caching so may need to split those star files, but opened 10 tomograms in test
August 25, 2026 at 7:39 PM
#cryoEM #cryoET #teamTOMO #Relion ❄️🔬
#IMOD /DeepETPicker style picker. Custom jobs for #SingleParticle and #Tomography. Not fully tested yet, little buggy on particle import. Have not stress tested the file caching so may need to split those star files, but opened 10 tomograms in test
#IMOD /DeepETPicker style picker. Custom jobs for #SingleParticle and #Tomography. Not fully tested yet, little buggy on particle import. Have not stress tested the file caching so may need to split those star files, but opened 10 tomograms in test
#cryoEM #cryoET #teamTOMO #Relion ❄️🔬
#IMOD / DeepETPicker style picks visualizer. You can use this little applet to open tomograms (or as a rudimentary volume viewer) right inside the interface. You can't edit picks here, but that might be something I add.
I plan to #supportLT along side Relion
#IMOD / DeepETPicker style picks visualizer. You can use this little applet to open tomograms (or as a rudimentary volume viewer) right inside the interface. You can't edit picks here, but that might be something I add.
I plan to #supportLT along side Relion
August 24, 2026 at 1:35 PM
August 18, 2026 at 4:07 PM
Excited to present my work on the CAR T cell immune synapse at #ICET2026 in Madison! So many inspiring talks and exciting advances in cryo-ET. Also loved touring the Midwest Center for Cryo-Electron Tomography! 🔬
#CryoET #CryoEM #ElectronTomography #StructuralBiology #CARTcells #teamtomo
#CryoET #CryoEM #ElectronTomography #StructuralBiology #CARTcells #teamtomo
August 17, 2026 at 7:31 PM
Excited to present my work on the CAR T cell immune synapse at #ICET2026 in Madison! So many inspiring talks and exciting advances in cryo-ET. Also loved touring the Midwest Center for Cryo-Electron Tomography! 🔬
#CryoET #CryoEM #ElectronTomography #StructuralBiology #CARTcells #teamtomo
#CryoET #CryoEM #ElectronTomography #StructuralBiology #CARTcells #teamtomo
After spending part of the last 2 weeks trying to get a #tomography pipeline up and running.... I have a flow!
#DeepETPicker and #ReLiOn. Its quite easy to manually pick particles in DeepETPicker even though they tell you import from IMOD. Just jump to the last tab and use mutual picking.
#teamtomo
#DeepETPicker and #ReLiOn. Its quite easy to manually pick particles in DeepETPicker even though they tell you import from IMOD. Just jump to the last tab and use mutual picking.
#teamtomo
August 14, 2026 at 12:51 PM
After spending part of the last 2 weeks trying to get a #tomography pipeline up and running.... I have a flow!
#DeepETPicker and #ReLiOn. Its quite easy to manually pick particles in DeepETPicker even though they tell you import from IMOD. Just jump to the last tab and use mutual picking.
#teamtomo
#DeepETPicker and #ReLiOn. Its quite easy to manually pick particles in DeepETPicker even though they tell you import from IMOD. Just jump to the last tab and use mutual picking.
#teamtomo
Then we teamed up w/ @weiss-lab.bsky.social & his awesome student Karolina, who took some amazing tomograms, showing Δcse mutant "almost free from any junctions" #TeamTomo
Some Add on, we also found that CSE likely interacting w/ an amidase that drills & builds up the #nanopores "explaining a lot"
Some Add on, we also found that CSE likely interacting w/ an amidase that drills & builds up the #nanopores "explaining a lot"
August 13, 2026 at 7:58 PM
Then we teamed up w/ @weiss-lab.bsky.social & his awesome student Karolina, who took some amazing tomograms, showing Δcse mutant "almost free from any junctions" #TeamTomo
Some Add on, we also found that CSE likely interacting w/ an amidase that drills & builds up the #nanopores "explaining a lot"
Some Add on, we also found that CSE likely interacting w/ an amidase that drills & builds up the #nanopores "explaining a lot"
🧵
#Bacterial #Multicellularity: We discovered that Ca2+ signaling controls cellular junctions in #cyanobacteria, similar to Euks @embojournal.org
A great collab. w/ @weiss-lab.bsky.social #TeamTomo
@hhu.de @spp2389.bsky.social @cmfi.bsky.social @mibinet.bsky.social
link.springer.com/article/10.1...
#Bacterial #Multicellularity: We discovered that Ca2+ signaling controls cellular junctions in #cyanobacteria, similar to Euks @embojournal.org
A great collab. w/ @weiss-lab.bsky.social #TeamTomo
@hhu.de @spp2389.bsky.social @cmfi.bsky.social @mibinet.bsky.social
link.springer.com/article/10.1...
The calcium-binding protein CSE links Ca2+ signaling with cell-cell communication in cyanobacteria - The EMBO Journal
Multicellular cyanobacteria have evolved sophisticated cell–cell communication machinery to exchange, synchronize, and coordinate the efforts of individual cells. Analogous to gap junctions that have ...
link.springer.com
August 13, 2026 at 5:54 PM
🧵
#Bacterial #Multicellularity: We discovered that Ca2+ signaling controls cellular junctions in #cyanobacteria, similar to Euks @embojournal.org
A great collab. w/ @weiss-lab.bsky.social #TeamTomo
@hhu.de @spp2389.bsky.social @cmfi.bsky.social @mibinet.bsky.social
link.springer.com/article/10.1...
#Bacterial #Multicellularity: We discovered that Ca2+ signaling controls cellular junctions in #cyanobacteria, similar to Euks @embojournal.org
A great collab. w/ @weiss-lab.bsky.social #TeamTomo
@hhu.de @spp2389.bsky.social @cmfi.bsky.social @mibinet.bsky.social
link.springer.com/article/10.1...