#NKCell
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jlbjournal.bsky.social
Capucine Bourel and colleagues @umontreal.ca @umontreal-en.bsky.social report that #MHC I shapes mouse #NKcell functional maturation
Mouse NK cell functional maturation is dependent on MHC I
MHC I shapes mouse NK cell functional maturation stages independently of effector protein expression. In other words, the expression of effector proteins c
doi.org
September 25, 2026 at 4:06 PM
jlbjournal.bsky.social
Jiongming He, Shan Liu, Lingying Wang & Fei Xiong report that #EsophagealCancer cells impair #NKcell function via the downregulation of #ZNF600 expression through the ligation of #CEACAM1 with #TIM3
Zinc finger protein 600 is essential for the cytotoxic function of esophageal cancer-associated natural killer cells
ZNF600 enhances the cytolytic activity of NK cells. EC cells downregulate ZNF600 expression in EC-associated NK cells via the ligation of CEACAM1 to TIM-3
doi.org
September 18, 2026 at 4:06 PM
jlbjournal.bsky.social
@brita-o.bsky.social and colleagues @gwibs.bsky.social show that platelet activation due to #HIV infection increases #Platelet-#NKcell complexes, which have distinct phenotypes and may alter the total NK cell population in people living with the virus
Circulating platelet-natural killer cell complexes are elevated in people living with human immunodeficiency virus on antiretroviral therapy
Platelet activation due to human immunodeficiency virus infection increases platelet-natural killer (NK) complexes, which have distinct phenotypes and may
doi.org
September 16, 2026 at 4:06 PM
fogspray.bsky.social
Product Description
Recombinant Human Interleukin-2 (IL-2) is a 15–16 kDa glycoprotein cytokine produced via recombinant DNA technology in either E. coli or mammalian expression systems. #highpuritychemical
arizona-mall.com/product/reco...
Recombinant Human Interleukin-2 | Lyophilized Powder | High-Purity Bulk Research Grade
Recombinant Human Interleukin2 Injection (brand name: Intecron®) is a biologic cytokine used in research to modulate immune responses, including Tcell and NKcell stimulation. Packaged as 100,000IU per vial (×10 vials), manufactured by Jiangsu Jinsili Pharmaceutical Co., Ltd. (NMPA No.S10970055; Code86901459000064; barcode6921098080344). Strictly for laboratory research use Please consult the staff for other purposes.
arizona-mall.com
November 17, 2025 at 4:24 PM
medcomm.bsky.social
#Highlight in #MedComm_Oncology
#Metabolic Reprogramming of the Pre-Metastatic Niche: A Sweet Spot for Anti-#Tumor #Immunity doi.org/10.1002/mog2...

The highlighted article in @CellCellPress : doi.org/10.1016/j.ce...

#LowCarbohydrateDiet #Lung #Metastasis #macrophage #NKcell
February 28, 2026 at 2:44 AM
medcomm.bsky.social
#Article in #MedComm
Low Dose of #IL_2 Application for Graft-Versus-Host Disease (#GVHD) Prophylaxis Following Haploidentical Stem Cell Transplantation doi.org/10.1002/mco2...

#Tregs #interleukin_2 #NKcell
January 16, 2026 at 3:43 AM
oncodaily.bsky.social
Boosting CAR-T/NK Cell Persistence via the FAS Pathway - Yan Leyfman
@yleyfman.bsky.social

oncodaily.com/blog/yan-ley...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #CART #NKCell
Yan Leyfman: Boosting CAR-T/NK Cell Persistence via the FAS Pathway - OncoDaily
Yan Leyfman: Boosting CAR-T/NK Cell Persistence via the FAS Pathway / cancer, Christopher A. Klebanoff, Christopher S Hackett, Doron Betel, Dr. Christopher A.
oncodaily.com
July 24, 2025 at 11:14 PM
oncodaily.bsky.social
Ammonia: A Hidden Obstacle in Cancer Immunotherapy - Yan Leyfman
@yleyfman.bsky.social

oncodaily.com/science/2665...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Ammonia #Immunotherapy #CART #NaturaKillerCells #NKcell
April 3, 2025 at 7:34 PM
oncodaily.bsky.social
How fasting reshapes NK cell biology to enhance anti-tumor immunity - Maria (Masha) Babak
@thebabaklab.bsky.social

oncodaily.com/blog/255068-...

#Cancer #CancerResearch #CancerTreatment #FightAgainstCancer #NKCell #Medicine #Health #Oncology #OncoDaily
Maria (Masha) Babak: How fasting reshapes NK cell biology to enhance anti-tumor immunity - OncoDaily
Maria (Masha) Babak: How fasting reshapes NK cell biology to enhance anti-tumor immunity / cancer, cancer therapy, fight against cancer, Global fight against
oncodaily.com
March 13, 2025 at 9:05 PM
drmiguelperales.bsky.social
3/3 #NKcell recovery @ day 30 strongly predicts better OS & PFS. One-log increase in NK count was associated with 36% ⬇️ in mortality risk. CD4 Tcell & B cell recovery were not linked to OS/PFS. Inflammatory cytokines and biomarkers were inversely related to NK cell recovery #CARTcells
December 14, 2024 at 2:48 PM
drnatsampaio.bsky.social
@drnicolecampbell.bsky.social once again wowing us with a showstopper at the @ciiid-hudson.bsky.social Xmas party. Individual macarons shaped like different the cells we work on, including #macrophage #neuron #NKcell #astrocyte #bacteria #virus
Amazing! 🧪👩‍🍳
December 12, 2025 at 11:12 PM
pallettlab.bsky.social
Big shout out to one of our PhD students Steph who has presented at her first *proper* national conference - showcasing her work on the #NKcell regulation of T cells in #liver cancer.

Well done Steph!
January 7, 2025 at 1:36 PM
immunoeditor.bsky.social
In #ScienceImmunology last week, Zhang & al reported that the stability & expression of #ImmuneCheckpoint molecule #TIM3 is regulated by palmitoyltransferase DHHC9. Peptidic inhibitor of DHHC9 accelerates TIM-3 degradation & enhances #CARTCell & #NKCell #antitumor immunity!

bit.ly/SI_adp7302
Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity
Targeting TIM-3 palmitoylation mediated by DHHC9 enhances CAR-T cell– and NK cell–based tumor immunotherapy by suppressing immune exhaustion.
bit.ly
November 19, 2024 at 7:51 PM
immunoeditor.bsky.social
This week in #ScienceImmunology: Olivier Demaria, Eric Vivier, & al. use tetraspecific #NKCell engager (comprising an anti- #NKp46 Ab fragment + #IgG1 #Fc fragment + #IL2 variant + anti- #CD20 Ab) to target #BCell -specific #NonHodgkin #lymphoma (B-NHL) in mouse & NHP models!

bit.ly/SI_adp3720
Representative CD20 staining of spleen and mandibular lymph node sections from animals treated with vehicle or CD20-NKCE-IL2v (0.5 mg/kg). Scale bars: 3 mm
November 18, 2024 at 10:22 PM
drinfosec.bsky.social
Here's Zdenek's take on that same NKcell paper

"Rather than framing long COVID as a simple state of persistent systemic inflammation, this new study points toward a model of chronically dysregulated immunity in which NK-cell dysfunction may occupy..."

25-tweet 🧵
threadreaderapp.com/thread/20310...
Rather than framing long COVID as a simple state of persistent systemic inflammation, this new study points toward a model of chronically dysregulated immunity in which NK-cell dysfunction may occupy a central mechanistic role🧵
March 9, 2026 at 6:00 PM
itmat.bsky.social
Generating universal allogeneic CART (UCART) cells that evade #NKcell “missing-self” response w/ similar performance to autologous #CARTCell in vitro/vivo doi.org/10.1182/bloo... #CellTherapy #ImmunoTherapy #TranslationalScience
HLA-E single-chain trimer shields gene-edited allogeneic CAR T Cells from NK cell attack
Key Points. HLA-ESP-1C single chain trimer protects gene-edited (MHC-I/II/TCR/CD54/CD58 deficient) human allogeneic CAR T cells from lysis by NK cells.Univ
doi.org
April 8, 2026 at 4:22 PM
jlbjournal.bsky.social
Anna Nicolela and colleagues from the @jeanetteeb.bsky.social lab @bhcri.bsky.social show that "Adenosine drives suppression of CD16low #NKcell responses against #HGSC via #NKG2A:#HLA-E interactions"
Adenosine drives suppression of CD16low NK cell responses against HGSC via NKG2A:hLA-E interactions
Adenosine suppresses NK cell responsiveness, driving upregulation of HLA-E and its inhibitory receptor, NKG2A, in ovarian cancer.
doi.org
April 1, 2026 at 4:08 AM
jlbjournal.bsky.social
Leslie Chan @stanfordimmunology.bsky.social, Catherine Blish @blishlab.bsky.social and colleagues @stanfordmedicine.bsky.social identify #Interferon activation and #NKG2D expression as key determinants of #NKcell antibody-dependent cellular cytotoxicity (#ADCC) in #SARS-CoV-2 infection
Interferon stimulation and NKG2D expression drive enhanced natural killer cell antibody-dependent cellular cytotoxicity against viral infections
Integrated single-cell transcriptomics and functional assays reveal interferon signaling and NKG2D expression as drivers of antibody-dependent cellular cyt
doi.org
February 24, 2026 at 5:06 PM
davidfinlaytcd.bsky.social
“Glutamine sensing licenses cholesterol synthesis”

#glutamine interacts with SCAP to alter the ER to Golgi trafficking needed to activate #SREBP transcriptional response.

www.embopress.org/doi/full/10....

Is this relevant to #immunometabolism, such as SREBP-dependent #NKcell responses?
Glutamine sensing licenses cholesterol synthesis | The EMBO Journal
imageimageWhether cholesterol biosynthesis can be adjusted to the availability of input carbon sources remains unclear. This study demonstrates that glutamine is directly sensed by and required for ac...
www.embopress.org
January 5, 2025 at 11:10 PM
jax.org
Supported by a new R01 grant from the National Institute of Allergy and Infectious Diseases, the Paust lab intends to further evaluate novel pathways regulating NKcell function in influenza virus infection as a potential target for novel antiviral immunotherapies:
🧪🤝🖥️ 🧬 ⑂ #immunosky
bit.ly/3uH4Ieu
The roles of natural killer cells in influenza clearance and immune system regulation
Silke Paust is investigating the roles lung Natural Killer cells play in clearing influenza virus infection and preventing damage to healthy cells during infection.
bit.ly
February 23, 2024 at 2:52 PM
imtadvances.bsky.social
💥 Curious about #NKCells' role in targeting tumours? @unisouthampton researchers review advances in #NKcell #immunotherapy, including CAR-NK cells, NK cell engagers, cytokines & checkpoint inhibitors: 🔗 doi.org/10.1093/imma... (4/8)
Harnessing natural killer cell effector function against cancer
Summary. Natural killer (NK) cells are cytotoxic innate lymphoid cells that participate in anti-tumour and anti-viral immune responses. Their ability to ra
doi.org
February 4, 2025 at 11:25 AM
raydfci.bsky.social
Feeling great to have presented my work at #ASH25. What an amazing conference this has been! Thank you for the wonderful opportunity! Looking forward to the ASH meeting next year and hope to showcase again our work from @danafarber.bsky.social
#Hematology #leusm #lymsm #ashawards #NKCell
December 9, 2025 at 9:36 PM
raydfci.bsky.social
Excited to give an Oral Presentation of my work at the @ash.hematology.org Annual Meeting in Orlando, Florida on Dec 6th. Happy to have received the #AbstractAchievementAward
Looking forward to a great meeting and scientific discussions!
#ASH25 #ASHAwards #NKCell #Lymsm #Leusm #ImmunOnc #Hematology
November 29, 2025 at 7:12 PM
sigtrans-sttt.bsky.social
A phase 1b/2 trial shows that #allogeneic #NKcell therapy plus #chemotherapy is safe in #AdvancedPancreaticCancer, with 31.6% response; #MultiomicProfiling reveals NK/T‑cell subsets linked to outcomes, offering novel immune insights.

#OpenAccess in STTT: doi.org/10.1038/s413...
January 28, 2026 at 4:07 PM
sigtrans-sttt.bsky.social
Relapsed #AML drives #NKCell exhaustion via the NKG2A/HLA‑E axis and PI3K‑AKT suppression; blocking NKG2A or restoring #AktPhosphorylation enhances #cytotoxicity, highlighting a strategy to optimize NK cell‑based #immunotherapies. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...
Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia
doi.org
January 2, 2026 at 2:00 AM